This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LHX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,005,375–124,005,788 | 6.0 kb | Proximal (<10kb) | 88 | |
| chr9:124,006,796–124,007,345 | 4.4 kb | Proximal (<10kb) | 160 | |
| chr9:124,008,456–124,009,293 | 2.5 kb | Proximal (<10kb) | 302 | |
| chr9:124,010,900–124,012,625 | at TSS | At TSS | 465 | |
| chr9:124,012,707–124,013,310 | 940 bp | At TSS | 80 | |
| chr9:124,013,889–124,014,123 | 2.1 kb | Proximal (<10kb) | 72 |
Genomic view of the LHX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.