chr1:99,786,642–99,787,232

chr1 : 99,786,642 – 99,787,232

590 bp 125 TFs 7 linked genes

This 590 bp open chromatin element is linked to 7 target genes and is bound by 125 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FRRS1		20.2 kb	Distal	Multiome
AGL		63.5 kb	Distal	Multiome
ENSG00000228084		183.1 kb	Distal	Multiome
SLC35A3		183.1 kb	Distal	Multiome
MFSD14A		251.2 kb	Distal	Multiome+HiCAR
SASS6		346.1 kb	Distal	Multiome+HiCAR
TRMT13		346.3 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

125 transcription factors

ChIP K562 ENCFF492SKF 426 bp overlap

ASCL1 2 datasets

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 170 bp overlap

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 156 bp overlap

ASH2L 1 dataset

ChIP GM12878 ENCSR849WCQ.ASH2L.GM12878 578 bp overlap

ChIP GM12878 ENCSR000BQK.ATF2.GM12878 179 bp overlap

ATF7 2 datasets

ChIP GM12878 ENCFF037PYH 372 bp overlap

ChIP GM12878 ENCSR014YCR.ATF7.GM12878 219 bp overlap

Ascl2 1 dataset

Motif DE_48h DE_48h-Ascl2_MA0816.1 10 bp overlap

Motif DE_48h DE_48h-Atf3_MA1988.2 7 bp overlap

BACH2 1 dataset

ChIP B-cell_IL2 GSE102460.BACH2.B-cell_IL2 205 bp overlap

BATF 2 datasets

Motif DE_48h DE_48h-BATF_MA1634.2 7 bp overlap

ChIP GM12878 ENCFF954REE 231 bp overlap

BATF3 1 dataset

Motif DE_48h DE_48h-BATF3_MA0835.3 7 bp overlap

BATF::JUN 1 dataset

Motif DE_48h DE_48h-BATFJUN_MA0462.3 7 bp overlap

BCL11A 1 dataset

ChIP GM12878 ENCSR000BHA.BCL11A.GM12878 123 bp overlap

Motif DE_48h DE_48h-BNC2_MA1928.2 7 bp overlap

ChIP K-562_iBET-IFNG GSE138084.BRD2.K-562_iBET-IFNG 204 bp overlap

ChIP H-1_DE GSE126661.BRD3.H-1_DE 430 bp overlap

BRD4 8 datasets

ChIP GM15850_DMSO GSE99402.BRD4.GM15850_DMSO 590 bp overlap

ChIP GM15850_PA1_JQ1 GSE99402.BRD4.GM15850_PA1_JQ1 187 bp overlap

ChIP GM15850_Syn-TEF1 GSE99402.BRD4.GM15850_Syn-TEF1 590 bp overlap

ChIP K-562_DMSO-IFNG GSE138084.BRD4.K-562_DMSO-IFNG 398 bp overlap

ChIP K-562_iBET-BD1-IFNG GSE138084.BRD4.K-562_iBET-BD1-IFNG 211 bp overlap

ChIP K-562_iBET-BD2-IFNG GSE138084.BRD4.K-562_iBET-BD2-IFNG 459 bp overlap

ChIP MM1-S_JQ1_5NM GSE42355.BRD4.MM1-S_JQ1_5NM 196 bp overlap

ChIP MOLT-4_DMSO GSE79288.BRD4.MOLT-4_DMSO 212 bp overlap

Bach1::Mafk 1 dataset

Motif DE_48h DE_48h-Bach1Mafk_MA0591.2 12 bp overlap

ChIP GM12878 ENCSR860UHK.CBFB.GM12878 137 bp overlap

ChIP MM1-S_DMSO GSE42161.CDK9.MM1-S_DMSO 195 bp overlap

CREB1 1 dataset

ChIP GM12878 ENCFF870CVH 351 bp overlap

ChIP GM12878 ENCSR839XZU.CREM.GM12878 153 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 271 bp overlap

Motif DE_36h DE_36h-Crx_MA0467.3 6 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

ChIP GM12878 ENCFF681AJV 455 bp overlap

Dmbx1 2 datasets

Motif DE_36h DE_36h-Dmbx1_MA0883.2 10 bp overlap

Motif DE_48h DE_48h-Dmbx1_MA0883.2 10 bp overlap

Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap

ChIP GM12878 ENCFF266FYW 201 bp overlap

ChIP GM12878 ENCFF266FYW 280 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 297 bp overlap

ERF::FIGLA 1 dataset

Motif DE_48h DE_48h-ERFFIGLA_MA1934.2 13 bp overlap

ERF::NHLH1 1 dataset

Motif DE_48h DE_48h-ERFNHLH1_MA1938.2 16 bp overlap

Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap

ETV6 3 datasets

ChIP GM12878 ENCFF105ZMI 372 bp overlap

ChIP GM12878 ENCSR626VUC.ETV6.GM12878 320 bp overlap

ChIP GM12878 GSE97661.ETV6.GM12878 277 bp overlap

FERD3L 1 dataset

Motif DE_48h DE_48h-FERD3L_MA1485.1 14 bp overlap

FIGLA 1 dataset

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

FOSL1 1 dataset

Motif DE_48h DE_48h-FOSL1_MA0477.3 9 bp overlap

FOXA1 1 dataset

ChIP LNCaP_DHT24H GSE58428.FOXA1.LNCaP_DHT24H 337 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 563 bp overlap

ChIP DE DE-FOXA2-2 482 bp overlap

FOXM1 1 dataset

ChIP GM12878 ENCSR000BRU.FOXM1.GM12878 168 bp overlap

GATA2 2 datasets

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 537 bp overlap

ChIP DE DE-GATA4-2 590 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 270 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 439 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 578 bp overlap

ChIP DE DE-GATA6-2 590 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 342 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 267 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 590 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 360 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 499 bp overlap

ChIP foregut GSE117136.GATA6.foregut 379 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 353 bp overlap

Motif DE_36h DE_36h-GSC_MA0648.2 6 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

GSC2 2 datasets

Motif DE_36h DE_36h-GSC2_MA0891.2 6 bp overlap

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Gata3 2 datasets

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

HDAC2 1 dataset

ChIP GM12878 ENCSR330OEO.HDAC2.GM12878 246 bp overlap

ChIP GM12878 ENCFF653WYI 220 bp overlap

HMBOX1 3 datasets

ChIP K-562 ENCSR757IIU.HMBOX1.K-562 456 bp overlap

ChIP K562 ENCFF055GAZ 419 bp overlap

ChIP K562 ENCFF317JJX 409 bp overlap

IKZF1 9 datasets

ChIP GM12878 ENCFF616FJX 417 bp overlap

ChIP GM12878 ENCFF616FJX 216 bp overlap

ChIP GM12878 ENCFF753XDO 580 bp overlap

ChIP GM12878 ENCFF753XDO 336 bp overlap

ChIP GM12878 ENCFF824TGK 580 bp overlap

ChIP GM12878 ENCFF824TGK 380 bp overlap

ChIP K-562 ENCSR395HWC.IKZF1.K-562 369 bp overlap

ChIP K562 ENCFF348IBL 427 bp overlap

ChIP K562 ENCFF348IBL 456 bp overlap

IKZF2 7 datasets

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

ChIP GM12878 ENCFF238LYK 500 bp overlap

ChIP GM12878 ENCFF238LYK 293 bp overlap

ChIP GM12878 ENCFF918AID 463 bp overlap

ChIP GM12878 ENCFF918AID 253 bp overlap

ChIP GM12878 ENCSR680UQE.IKZF2.GM12878 514 bp overlap

ChIP GM12878 ENCSR822AHX.IKZF2.GM12878 349 bp overlap

IRF1 9 datasets

ChIP AsPC-1_IFNg GSE141606.IRF1.AsPC-1_IFNg 290 bp overlap

ChIP K-562 ENCSR854MCV.IRF1.K-562 590 bp overlap

ChIP K-562 GSE129380.IRF1.K-562 375 bp overlap

ChIP K-562 ENCSR000EGL.IRF1.K-562 246 bp overlap

ChIP K-562 ENCSR000EGU.IRF1.K-562 151 bp overlap

ChIP K-562 ENCSR000EGK.IRF1.K-562 139 bp overlap

ChIP K-562_EPZ GSE129380.IRF1.K-562_EPZ 444 bp overlap

ChIP K562 ENCFF277KTJ 204 bp overlap

ChIP K562 ENCFF277KTJ 385 bp overlap

IRF2 3 datasets

ChIP K-562 ENCSR376WCJ.IRF2.K-562 341 bp overlap

ChIP K562 ENCFF248LJZ 207 bp overlap

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 347 bp overlap

IRF4 2 datasets

ChIP B-cell GSE142493.IRF4.B-cell 319 bp overlap

ChIP GM12878 ENCSR000BGY.IRF4.GM12878 497 bp overlap

Ikzf3 1 dataset

Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 283 bp overlap

JUN::JUNB 1 dataset

Motif DE_48h DE_48h-JUNJUNB_MA1132.2 8 bp overlap

JUNB 3 datasets

Motif DE_48h DE_48h-JUNB_MA0490.3 9 bp overlap

ChIP GM12878 ENCFF667EJQ 113 bp overlap

ChIP GM12878 ENCSR897MMC.JUNB.GM12878 489 bp overlap

Motif DE_48h DE_48h-Jun_MA0489.3 8 bp overlap

ChIP OCI-AML-3 GSE133516.KAT7.OCI-AML-3 277 bp overlap

MAF::NFE2 1 dataset

Motif DE_48h DE_48h-MAFNFE2_MA0501.2 11 bp overlap

MAFG::NFE2L1 1 dataset

Motif DE_48h DE_48h-MAFGNFE2L1_MA0089.3 11 bp overlap

MAFK 2 datasets

Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap

ChIP OCI-Ly7 GSE47784.MAFK.OCI-Ly7 203 bp overlap

MED1 2 datasets

ChIP GM12878 GSE93080.MED1.GM12878 529 bp overlap

ChIP MM1-S_JQ1_50NM GSE49224.MED1.MM1-S_JQ1_50NM 231 bp overlap

MEIS1 4 datasets

Motif DE_36h DE_36h-MEIS1_MA1639.2 9 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA1639.2 9 bp overlap

ChIP SEM GSE38339.MEIS1.SEM 130 bp overlap

MEIS2 2 datasets

ChIP K-562 ENCSR851BNE.MEIS2.K-562 310 bp overlap

ChIP K562 ENCFF320GSD 371 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 52 bp overlap

ChIP GM12878 ENCSR293QAR.MTA2.GM12878 477 bp overlap

ChIP MOLT-3 GSE59657.MYB.MOLT-3 128 bp overlap

ChIP MOLT-3 GSE59657.MYB.MOLT-3 147 bp overlap

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Mecom 4 datasets

Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap

Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

ChIP GM12878 ENCSR278SQL.NBN.GM12878 177 bp overlap

NCOR1 1 dataset

ChIP LS180 GSE39277.NCOR1.LS180 93 bp overlap

NFIC 3 datasets

ChIP GM12878 ENCFF259FWL 584 bp overlap

ChIP GM12878 ENCFF259FWL 385 bp overlap

ChIP GM12878 ENCSR000BRN.NFIC.GM12878 590 bp overlap

NIPBL 1 dataset

ChIP GM12878 GSE93080.NIPBL.GM12878 527 bp overlap

Nfe2l2 1 dataset

Motif DE_48h DE_48h-Nfe2l2_MA0150.3 11 bp overlap

Nr2e1 2 datasets

Motif DE_36h DE_36h-Nr2e1_MA0676.1 9 bp overlap

Motif DE_48h DE_48h-Nr2e1_MA0676.1 9 bp overlap

ONECUT1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 169 bp overlap

OTX1 2 datasets

Motif DE_36h DE_36h-OTX1_MA0711.2 6 bp overlap

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

PAX5 4 datasets

ChIP GM12878 ENCFF482PUW 251 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 227 bp overlap

ChIP GM12878 ENCSR000BHD.PAX5.GM12878 199 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 165 bp overlap

PBX1 2 datasets

Motif DE_36h DE_36h-PBX1_MA0070.2 9 bp overlap

Motif DE_48h DE_48h-PBX1_MA0070.2 9 bp overlap

PBX2 2 datasets

ChIP K-562 ENCSR263DFP.PBX2.K-562 295 bp overlap

ChIP K562 ENCFF286KMN 401 bp overlap

ChIP GM12878 ENCSR000BGR.PBX3.GM12878 138 bp overlap

PDX1 2 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 243 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 332 bp overlap

PITX1 2 datasets

Motif DE_36h DE_36h-PITX1_MA0682.3 6 bp overlap

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

PITX3 2 datasets

Motif DE_36h DE_36h-PITX3_MA0714.2 6 bp overlap

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

PKNOX1 3 datasets

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 299 bp overlap

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 130 bp overlap

ChIP K562 ENCFF236IUS 115 bp overlap

ChIP GM12878 ENCFF160JQZ 253 bp overlap

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

ChIP GM12878 ENCSR387QUV.RELB.GM12878 521 bp overlap

RHOXF1 2 datasets

Motif DE_36h DE_36h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

RUNX3 1 dataset

ChIP GM12878 ENCFF395WHA 207 bp overlap

ChIP GM12878 ENCSR000BJD.RXRA.GM12878 214 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 235 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 579 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 356 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 266 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 465 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 468 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 209 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 282 bp overlap

SMARCA5 1 dataset

ChIP K-562 ENCSR895HSJ.SMARCA5.K-562 83 bp overlap

SOX10 2 datasets

Motif DE_36h DE_36h-SOX10_MA0442.3 6 bp overlap

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 538 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 485 bp overlap

SOX4 2 datasets

Motif DE_36h DE_36h-SOX4_MA0867.3 8 bp overlap

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

ChIP K-562 ENCSR788RSW.SOX6.K-562 272 bp overlap

SPI1 9 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 80 bp overlap

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 73 bp overlap

ChIP GM12878 ENCFF134LCP 106 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 71 bp overlap

ChIP HL-60 ENCFF645GBT 94 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 171 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 56 bp overlap

ChIP K562 ENCFF410ORC 63 bp overlap

ChIP OCI-Ly7 GSE69558.SPI1.OCI-Ly7 73 bp overlap

ChIP GM12878 ENCFF565AWY 201 bp overlap

ChIP GM12878 ENCFF878IIX 303 bp overlap

ChIP GM12878 ENCFF880MVC 241 bp overlap

ChIP GM12878 ENCSR041XML.SRF.GM12878 348 bp overlap

ChIP GM12878 ENCSR000BMI.SRF.GM12878 199 bp overlap

ChIP GM12878 ENCSR000BGE.SRF.GM12878 204 bp overlap

STAT2 1 dataset

ChIP K-562 ENCSR000FBC.STAT2.K-562 230 bp overlap

STAT3 2 datasets

Motif DE_36h DE_36h-STAT3_MA0144.3 9 bp overlap

Motif DE_48h DE_48h-STAT3_MA0144.3 9 bp overlap

Sox11 2 datasets

Motif DE_36h DE_36h-Sox11_MA0869.3 8 bp overlap

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

Stat5a 2 datasets

Motif DE_36h DE_36h-Stat5a_MA1624.2 9 bp overlap

Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap

Stat5a::Stat5b 2 datasets

Motif DE_36h DE_36h-Stat5aStat5b_MA0519.2 9 bp overlap

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

Stat6 1 dataset

Motif DE_48h DE_48h-Stat6_MA0520.2 10 bp overlap

TAF1 2 datasets

ChIP GM12878 ENCFF746UKX 331 bp overlap

ChIP GM12878 ENCSR000BGS.TAF1.GM12878 279 bp overlap

TAL1::TCF3 1 dataset

Motif DE_48h DE_48h-TAL1TCF3_MA0091.2 10 bp overlap

TBX21 1 dataset

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 391 bp overlap

TCF12 2 datasets

ChIP GM12878 ENCFF433DMU 337 bp overlap

ChIP GM12878 ENCSR000BGZ.TCF12.GM12878 524 bp overlap

TCF3 2 datasets

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 202 bp overlap

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 135 bp overlap

TFAP4::ETV1 1 dataset

Motif DE_48h DE_48h-TFAP4ETV1_MA1966.2 13 bp overlap

TRIM22 2 datasets

ChIP GM12878 ENCFF919OMX 223 bp overlap

ChIP GM12878 ENCSR835XKS.TRIM22.GM12878 327 bp overlap

TRPS1 2 datasets

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

ChIP GM12891 ENCFF460SIS 325 bp overlap

ChIP GM12891 ENCSR000BKJ.YY1.GM12891 156 bp overlap

ChIP GM12892 ENCSR000BLT.YY1.GM12892 121 bp overlap

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

ZFP64 2 datasets

ChIP HEK293 GSE76494.ZFP64.HEK293 418 bp overlap

ChIP Hep-G2 ENCSR487CPI.ZFP64.Hep-G2 364 bp overlap

ZNF213 1 dataset

Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap

ZNF549 1 dataset

Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap

Zfp335 1 dataset

Motif DE_48h DE_48h-Zfp335_MA2002.2 7 bp overlap