Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FRRS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRRS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRRS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:99,757,951–99,758,464 | 8.2 kb | Proximal (<10kb) | 125 | |
| chr1:99,765,318–99,766,122 | 512 bp | At TSS | 145 | |
| chr1:99,766,329–99,767,002 | at TSS | At TSS | 512 | |
| chr1:99,771,611–99,772,270 | 5.0 kb | Proximal (<10kb) | 162 | |
| chr1:99,773,872–99,774,073 | 7.2 kb | Proximal (<10kb) | 39 | |
| chr1:99,786,642–99,787,232 | 20.2 kb | Distal (>10kb) Multiome | 125 | |
| chr1:99,835,815–99,836,689 | 69.7 kb | Distal (>10kb) Multiome | 129 | |
| chr1:99,849,521–99,850,730 | 83.5 kb | Distal (>10kb) Multiome | 968 | |
| chr1:99,944,156–99,945,039 | 178.1 kb | Distal (>10kb) Multiome | 68 | |
| chr1:99,950,389–99,951,124 | 184.0 kb | Distal (>10kb) Multiome | 109 | |
| chr1:99,951,388–99,951,903 | 185.0 kb | Distal (>10kb) Multiome | 18 | |
| chr1:99,959,336–99,959,871 | 193.0 kb | Distal (>10kb) Multiome | 103 | |
| chr1:99,969,317–99,970,703 | 203.5 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:100,037,569–100,039,066 | 271.5 kb | Distal (>10kb) Multiome | 979 | |
| chr1:100,048,184–100,049,196 | 282.1 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the FRRS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.