The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for FOXM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:2,691,016–2,691,920 | 185.3 kb | Distal (>10kb) Multiome | 194 | |
| chr12:2,752,645–2,753,234 | 124.2 kb | Distal (>10kb) Multiome | 945 | |
| chr12:2,794,243–2,796,266 | 81.0 kb | Distal (>10kb) Multiome | 802 | |
| chr12:2,812,386–2,813,317 | 64.3 kb | Distal (>10kb) Multiome | 1037 | |
| chr12:2,845,941–2,846,561 | 30.9 kb | Distal (>10kb) Multiome | 220 | |
| chr12:2,876,673–2,877,899 | 209 bp | At TSS Multiome | 809 | |
| chr12:2,885,311–2,885,536 | 8.3 kb | Proximal (<10kb) | 301 | |
| chr12:2,890,285–2,891,599 | 13.8 kb | Distal (>10kb) Multiome | 880 | |
| chr12:2,958,171–2,960,222 | 82.3 kb | Distal (>10kb) Multiome | 770 | |
| chr12:3,076,742–3,077,982 | 200.3 kb | Distal (>10kb) Multiome | 614 | |
| chr12:3,172,314–3,172,997 | 295.7 kb | Distal (>10kb) Multiome | 53 |
Genomic view of the FOXM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.