This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. This gene is also associated with susceptibility to adolescent idiopathic scoliosis. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for BNC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BNC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BNC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:16,708,458–16,709,357 | 161.9 kb | Distal (>10kb) Multiome | 149 | |
| chr9:16,726,627–16,727,460 | 143.7 kb | Distal (>10kb) Multiome | 457 | |
| chr9:16,809,925–16,810,972 | 60.3 kb | Distal (>10kb) Multiome | 283 | |
| chr9:16,869,468–16,869,841 | 1.8 kb | Proximal (<10kb) | 122 | |
| chr9:16,869,935–16,872,271 | 121 bp | At TSS Multiome | 468 | |
| chr9:17,080,891–17,082,079 | 210.6 kb | Distal (>10kb) Multiome | 179 | |
| chr9:17,134,290–17,135,974 | 264.3 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the BNC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.