Transcription factors with Perturb-seq knockdown data for ENSG00000228084. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000228084 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000228084, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:99,786,642–99,787,232 | 183.1 kb | Distal (>10kb) Multiome | 125 | |
| chr1:99,835,815–99,836,689 | 133.6 kb | Distal (>10kb) Multiome | 129 | |
| chr1:99,849,521–99,850,730 | 119.8 kb | Distal (>10kb) Multiome | 968 | |
| chr1:99,944,156–99,945,039 | 25.2 kb | Distal (>10kb) Multiome | 68 | |
| chr1:99,950,389–99,951,124 | 19.3 kb | Distal (>10kb) Multiome | 109 | |
| chr1:99,951,388–99,951,903 | 18.3 kb | Distal (>10kb) Multiome | 18 | |
| chr1:99,959,336–99,959,871 | 10.4 kb | Distal (>10kb) Multiome | 103 | |
| chr1:99,963,408–99,963,825 | 6.1 kb | Proximal (<10kb) | 45 | |
| chr1:99,969,317–99,970,703 | 194 bp | At TSS Multiome | 1091 | |
| chr1:100,037,569–100,039,066 | 68.2 kb | Distal (>10kb) Multiome | 979 | |
| chr1:100,048,184–100,049,196 | 78.8 kb | Distal (>10kb) Multiome | 234 | |
| chr1:100,132,347–100,133,463 | 163.0 kb | Distal (>10kb) Multiome | 947 | |
| chr1:100,249,217–100,250,325 | 279.9 kb | Distal (>10kb) Multiome | 803 | |
| chr1:100,265,673–100,266,819 | 296.3 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the ENSG00000228084 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.