Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD14A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD14A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD14A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:99,786,642–99,787,232 | 251.2 kb | Distal (>10kb) Multiome HiCAR | 125 | |
| chr1:99,835,815–99,836,689 | 201.8 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr1:99,849,521–99,850,730 | 187.9 kb | Distal (>10kb) Multiome | 968 | |
| chr1:99,944,156–99,945,039 | 93.4 kb | Distal (>10kb) Multiome | 68 | |
| chr1:99,950,389–99,951,124 | 87.5 kb | Distal (>10kb) Multiome | 109 | |
| chr1:99,951,388–99,951,903 | 86.4 kb | Distal (>10kb) Multiome | 18 | |
| chr1:99,959,336–99,959,871 | 78.5 kb | Distal (>10kb) Multiome | 103 | |
| chr1:99,969,317–99,970,703 | 67.9 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:100,036,769–100,037,395 | 698 bp | At TSS | 171 | |
| chr1:100,037,569–100,039,066 | 41 bp | At TSS Multiome | 979 | |
| chr1:100,048,184–100,049,196 | 10.6 kb | Distal (>10kb) Multiome | 234 | |
| chr1:100,132,347–100,133,463 | 94.9 kb | Distal (>10kb) Multiome | 947 | |
| chr1:100,249,217–100,250,325 | 211.8 kb | Distal (>10kb) Multiome | 803 | |
| chr1:100,265,673–100,266,819 | 228.1 kb | Distal (>10kb) Multiome | 796 | |
| chr1:100,337,594–100,338,776 | 300.0 kb | Distal (>10kb) Multiome | 109 |
Genomic view of the MFSD14A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.