This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for ONECUT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ONECUT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ONECUT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,528,126–52,529,827 | 261.3 kb | Distal (>10kb) Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 221.3 kb | Distal (>10kb) Multiome | 996 | |
| chr15:52,677,739–52,679,973 | 110.9 kb | Distal (>10kb) Multiome | 913 | |
| chr15:52,699,116–52,699,867 | 90.7 kb | Distal (>10kb) Multiome | 140 | |
| chr15:52,709,542–52,710,221 | 80.5 kb | Distal (>10kb) Multiome | 335 | |
| chr15:52,745,306–52,746,160 | 44.5 kb | Distal (>10kb) Multiome | 166 | |
| chr15:52,780,603–52,780,786 | 9.5 kb | Proximal (<10kb) | 238 | |
| chr15:52,783,424–52,785,757 | 6.7 kb | Proximal (<10kb) Multiome | 397 | |
| chr15:52,785,842–52,786,080 | 4.3 kb | Proximal (<10kb) | 56 | |
| chr15:52,786,459–52,787,951 | 2.4 kb | Proximal (<10kb) | 288 | |
| chr15:52,788,045–52,788,796 | 1.5 kb | Proximal (<10kb) | 112 | |
| chr15:52,789,439–52,791,791 | 88 bp | At TSS Multiome | 633 | |
| chr15:52,792,602–52,792,764 | 2.3 kb | Proximal (<10kb) | 13 | |
| chr15:52,792,897–52,793,251 | 2.6 kb | Proximal (<10kb) | 14 | |
| chr15:52,798,074–52,799,220 | 8.6 kb | Proximal (<10kb) Multiome | 184 | |
| chr15:52,804,516–52,806,560 | 15.4 kb | Distal (>10kb) Multiome | 322 | |
| chr15:53,758,987–53,760,031 | 969.3 kb | Distal (>10kb) Multiome HiCAR | 192 |
Genomic view of the ONECUT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.