chr1 : 18,090,558 – 18,091,301
743 bp 112 TFs 1 linked gene
This 743 bp open chromatin element is linked to IGSF21 and is bound by 112 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
IGSF21 16.9 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr1:18,085,558 – 18,096,301
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
112 transcription factors
Source
Cell type
ARID1A 1 dataset
ChIP NGP GSE134626.ARID1A.NGP 226 bp overlap
ASH2L 2 datasets
ChIP H1 ENCFF399KAM 638 bp overlap
ChIP WA01 ENCSR850KIP.ASH2L.WA01 620 bp overlap
ATF2 3 datasets
ChIP H1 ENCFF295GZO 480 bp overlap
ChIP H1 ENCFF295GZO 571 bp overlap
ChIP WA01 ENCSR000BQU.ATF2.WA01 174 bp overlap
BCOR 2 datasets
ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 168 bp overlap
ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 192 bp overlap
BRD4 9 datasets
ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 242 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 321 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 56 bp overlap
ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 397 bp overlap
ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 322 bp overlap
ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 742 bp overlap
ChIP cortical-interneuron_R133C_KCl-neg_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-neg_JQ1-neg 221 bp overlap
ChIP cortical-interneuron_R133C_KCl-pos_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-pos_JQ1-neg 435 bp overlap
ChIP hESC GSE33281.BRD4.hESC 72 bp overlap
CEBPB 1 dataset
ChIP WA01 ENCSR000EBV.CEBPB.WA01 213 bp overlap
CREB1 1 dataset
ChIP WA01 ENCSR000BSN.CREB1.WA01 103 bp overlap
CTBP2 2 datasets
ChIP H1 ENCFF329MAX 591 bp overlap
ChIP WA01 ENCSR000EUO.CTBP2.WA01 397 bp overlap
CTCF 1 dataset
ChIP endodermal cell ENCFF471YCZ 461 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF031ISE 443 bp overlap
Crx 2 datasets
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
DMRTA2 2 datasets
Motif DE_48h DE_48h-DMRTA2_MA1478.2 6 bp overlap
Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap
DUX4 2 datasets
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap
Ddit3::Cebpa 1 dataset
Motif DE_72h DE_72h-Ddit3Cebpa_MA0019.2 10 bp overlap
E2F6 2 datasets
ChIP H1 ENCFF785DWK 311 bp overlap
ChIP WA01 ENCSR000BSI.E2F6.WA01 603 bp overlap
EBF1 1 dataset
ChIP MUTUL GSE75503.EBF1.MUTUL 204 bp overlap
ELF1 1 dataset
ChIP GM12878 ENCSR000BMB.ELF1.GM12878 140 bp overlap
ELF2 1 dataset
Motif DE_72h DE_72h-ELF2_MA1483.3 10 bp overlap
ELL2 1 dataset
ChIP HeLa_DOX_EGF GSE40632.ELL2.HeLa_DOX_EGF 154 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 360 bp overlap
ETV1 1 dataset
Motif DE_72h DE_72h-ETV1_MA0761.3 9 bp overlap
EWSR1-FLI1 2 datasets
Motif DE_48h DE_48h-EWSR1-FLI1_MA0149.1 18 bp overlap
Motif DE_72h DE_72h-EWSR1-FLI1_MA0149.1 18 bp overlap
FIGLA 1 dataset
Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 282 bp overlap
ChIP DE DE-FOXA2-2 264 bp overlap
FOXO1::ELK1 1 dataset
Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap
GATA2 1 dataset
ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 182 bp overlap
GATA4 5 datasets
ChIP DE DE-GATA4-1 594 bp overlap
ChIP DE DE-GATA4-2 689 bp overlap
ChIP foregut GSE117136.GATA4.foregut 485 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 338 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 274 bp overlap
GATA5 2 datasets
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 12 datasets
ChIP DE DE-GATA6-1 611 bp overlap
ChIP DE DE-GATA6-2 631 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 569 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 623 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 533 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 743 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 664 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 570 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 626 bp overlap
ChIP foregut GSE117136.GATA6.foregut 459 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 484 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 411 bp overlap
GSC 2 datasets
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 2 datasets
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
GTF3C2 1 dataset
ChIP H9 GSE94418.GTF3C2.H9 253 bp overlap
Gli1 2 datasets
Motif DE_48h DE_48h-Gli1_MA1990.2 10 bp overlap
Motif DE_72h DE_72h-Gli1_MA1990.2 10 bp overlap
Gli2 2 datasets
Motif DE_48h DE_48h-Gli2_MA0734.4 9 bp overlap
Motif DE_72h DE_72h-Gli2_MA0734.4 9 bp overlap
IKZF2 1 dataset
Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap
Ikzf3 1 dataset
Motif DE_72h DE_72h-Ikzf3_MA1992.2 9 bp overlap
JUN 4 datasets
ChIP DE_D1 S40-DE-d1-JUN-exp2 362 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 544 bp overlap
ChIP HUES-8 GSE109524.JUN.HUES-8 280 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 292 bp overlap
KDM4A 1 dataset
ChIP WA01 ENCSR000AVC.KDM4A.WA01 146 bp overlap
KLF10 2 datasets
Motif DE_48h DE_48h-KLF10_MA1511.2 9 bp overlap
Motif DE_72h DE_72h-KLF10_MA1511.2 9 bp overlap
KLF12 2 datasets
Motif DE_48h DE_48h-KLF12_MA0742.2 9 bp overlap
Motif DE_72h DE_72h-KLF12_MA0742.2 9 bp overlap
KLF14 2 datasets
Motif DE_48h DE_48h-KLF14_MA0740.2 9 bp overlap
Motif DE_72h DE_72h-KLF14_MA0740.2 9 bp overlap
KLF16 2 datasets
Motif DE_48h DE_48h-KLF16_MA0741.1 11 bp overlap
Motif DE_72h DE_72h-KLF16_MA0741.1 11 bp overlap
KLF5 2 datasets
Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap
Motif DE_72h DE_72h-KLF5_MA0599.1 10 bp overlap
MAX 6 datasets
ChIP H1 ENCFF914VQY 245 bp overlap
ChIP NCI-H128 GSE41105.MAX.NCI-H128 285 bp overlap
ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 478 bp overlap
ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 309 bp overlap
ChIP WA01 ENCSR000EUP.MAX.WA01 162 bp overlap
ChIP WA01 ENCSR000EUP.MAX.WA01 238 bp overlap
MAZ 2 datasets
Motif DE_48h DE_48h-MAZ_MA1522.2 8 bp overlap
Motif DE_72h DE_72h-MAZ_MA1522.2 8 bp overlap
MORC2 1 dataset
ChIP H9 GSE95374.MORC2.H9 312 bp overlap
MYC 2 datasets
ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 242 bp overlap
ChIP NCI-H2171 GSE41105.MYC.NCI-H2171 173 bp overlap
MYCN 1 dataset
ChIP CHP-134 GSE129588.MYCN.CHP-134 283 bp overlap
MZF1 1 dataset
Motif DE_72h DE_72h-MZF1_MA0056.3 8 bp overlap
NANOG 2 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 484 bp overlap
ChIP hESC GSE18292.NANOG.hESC 93 bp overlap
NR1I2 1 dataset
Motif DE_72h DE_72h-NR1I2_MA1533.2 15 bp overlap
OTX1 2 datasets
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
PATZ1 2 datasets
Motif DE_48h DE_48h-PATZ1_MA1961.2 11 bp overlap
Motif DE_72h DE_72h-PATZ1_MA1961.2 11 bp overlap
PHIP 1 dataset
ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 290 bp overlap
PITX1 2 datasets
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 2 datasets
Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 2 datasets
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
POU5F1 4 datasets
ChIP BG03 GSE21614.POU5F1.BG03 238 bp overlap
ChIP DE_D1 DED1-OCT4_Batch_II 452 bp overlap
ChIP HUES-8 GSE109524.POU5F1.HUES-8 389 bp overlap
ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 345 bp overlap
Prdm15 1 dataset
Motif DE_72h DE_72h-Prdm15_MA1616.2 11 bp overlap
RAD21 2 datasets
ChIP RH4 GSE83726.RAD21.RH4 319 bp overlap
ChIP neural ENCSR198ZYJ.RAD21.neural 342 bp overlap
RBBP5 1 dataset
ChIP WA01 ENCSR000AQC.RBBP5.WA01 287 bp overlap
RHOXF1 2 datasets
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
RUNX1 1 dataset
ChIP K-562 ENCSR588AKU.RUNX1.K-562 214 bp overlap
RYBP 1 dataset
ChIP WA01 GSE104690.RYBP.WA01 743 bp overlap
Runx1 2 datasets
Motif DE_48h DE_48h-Runx1_MA0002.3 9 bp overlap
Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap
SIX1 2 datasets
Motif DE_48h DE_48h-SIX1_MA1118.2 9 bp overlap
Motif DE_72h DE_72h-SIX1_MA1118.2 9 bp overlap
SIX2 4 datasets
Motif DE_48h DE_48h-SIX2_MA1119.2 11 bp overlap
Motif DE_72h DE_72h-SIX2_MA1119.2 11 bp overlap
ChIP HEK GSE73865.SIX2.HEK 268 bp overlap
ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 208 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 214 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 723 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 410 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 428 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 283 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 381 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 647 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 743 bp overlap
SMARCA4 1 dataset
ChIP hiPSC GSE124903.SMARCA4.hiPSC 285 bp overlap
SMARCB1 2 datasets
ChIP hiPSC GSE124903.SMARCB1.hiPSC 421 bp overlap
ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 219 bp overlap
SMARCC1 3 datasets
ChIP DE_D1 S15-DE-d1-BAF155-exp1 416 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 452 bp overlap
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 178 bp overlap
SOX10 2 datasets
Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap
Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 533 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 582 bp overlap
SOX2 1 dataset
ChIP hiPSC GSE56567.SOX2.hiPSC 313 bp overlap
SOX21 1 dataset
ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 286 bp overlap
SP1 4 datasets
Motif DE_48h DE_48h-SP1_MA0079.5 9 bp overlap
Motif DE_72h DE_72h-SP1_MA0079.5 9 bp overlap
ChIP H1 ENCFF263FUH 321 bp overlap
ChIP WA01 ENCSR000BIR.SP1.WA01 271 bp overlap
SP2 2 datasets
Motif DE_48h DE_48h-SP2_MA0516.3 9 bp overlap
Motif DE_72h DE_72h-SP2_MA0516.3 9 bp overlap
SP3 2 datasets
Motif DE_48h DE_48h-SP3_MA0746.3 11 bp overlap
Motif DE_72h DE_72h-SP3_MA0746.3 11 bp overlap
SP4 3 datasets
Motif DE_48h DE_48h-SP4_MA0685.2 9 bp overlap
Motif DE_72h DE_72h-SP4_MA0685.2 9 bp overlap
ChIP HEK293 GSE76494.SP4.HEK293 152 bp overlap
SP5 4 datasets
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap
Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap
Sox11 2 datasets
Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap
Motif DE_72h DE_72h-Sox11_MA0869.3 8 bp overlap
Sox6 2 datasets
Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap
Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap
Stat5a 2 datasets
Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap
Motif DE_72h DE_72h-Stat5a_MA1624.2 9 bp overlap
T 1 dataset
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 183 bp overlap
TCF7L2 1 dataset
ChIP HCT-116 ENCSR000EUV.TCF7L2.HCT-116 137 bp overlap
TEAD4 1 dataset
ChIP ESC S26-ESC-d0-TEAD4-exp1 263 bp overlap
TFAP2C 1 dataset
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 229 bp overlap
TRIM28 1 dataset
ChIP hESC GSE115387.TRIM28.hESC 212 bp overlap
USF1 1 dataset
ChIP WA01 ENCSR000BIU.USF1.WA01 177 bp overlap
Wt1 2 datasets
Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap
Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap
YY1 4 datasets
ChIP H1 ENCFF524BTL 337 bp overlap
ChIP NT2-D1 ENCSR000EXG.YY1.NT2-D1 229 bp overlap
ChIP NT2/D1 ENCFF999MII 325 bp overlap
ChIP WA01 ENCSR000BKD.YY1.WA01 340 bp overlap
Yy1 2 datasets
Motif DE_48h DE_48h-Yy1_MA0095.4 8 bp overlap
Motif DE_72h DE_72h-Yy1_MA0095.4 8 bp overlap
ZBTB24 2 datasets
Motif DE_48h DE_48h-ZBTB24_MA2330.1 10 bp overlap
Motif DE_72h DE_72h-ZBTB24_MA2330.1 10 bp overlap
ZEB1 1 dataset
Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap
ZFHX2 1 dataset
ChIP HEK293 ENCFF167TUA 220 bp overlap
ZFP42 2 datasets
Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap
Motif DE_72h DE_72h-ZFP42_MA1651.2 13 bp overlap
ZNF148 2 datasets
Motif DE_48h DE_48h-ZNF148_MA1653.2 10 bp overlap
Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap
ZNF189 1 dataset
ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 252 bp overlap
ZNF281 4 datasets
Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap
Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap
ChIP K-562 GSE121133.ZNF281.K-562 213 bp overlap
ChIP WTC11 ENCFF551GAV 377 bp overlap
ZNF320 2 datasets
Motif DE_48h DE_48h-ZNF320_MA1976.2 20 bp overlap
Motif DE_72h DE_72h-ZNF320_MA1976.2 20 bp overlap
ZNF331 1 dataset
Motif DE_72h DE_72h-ZNF331_MA1726.2 10 bp overlap
ZNF350 1 dataset
ChIP HEK293 GSE76494.ZNF350.HEK293 215 bp overlap
ZNF398 1 dataset
ChIP H9 GSE133630.ZNF398.H9 154 bp overlap
ZNF467 1 dataset
ChIP HEK293 GSE76494.ZNF467.HEK293 61 bp overlap
ZNF574 2 datasets
Motif DE_48h DE_48h-ZNF574_MA1982.2 14 bp overlap
Motif DE_72h DE_72h-ZNF574_MA1982.2 14 bp overlap
ZNF582 1 dataset
Motif DE_72h DE_72h-ZNF582_MA1983.2 19 bp overlap
ZSCAN16 2 datasets
Motif DE_48h DE_48h-ZSCAN16_MA2100.1 18 bp overlap
Motif DE_72h DE_72h-ZSCAN16_MA2100.1 18 bp overlap
Zfp335 1 dataset
Motif DE_72h DE_72h-Zfp335_MA2002.2 7 bp overlap
Zfx 1 dataset
Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap
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