Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of DNA-templated transcription; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ELF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:138,816,572–138,817,315 | 267.3 kb | Distal (>10kb) Multiome | 211 | |
| chr4:138,910,598–138,911,729 | 173.3 kb | Distal (>10kb) Multiome | 566 | |
| chr4:138,936,704–138,937,523 | 147.3 kb | Distal (>10kb) Multiome | 74 | |
| chr4:138,974,508–138,975,556 | 109.6 kb | Distal (>10kb) Multiome | 150 | |
| chr4:139,014,635–139,016,468 | 68.6 kb | Distal (>10kb) Multiome | 975 | |
| chr4:139,020,400–139,021,056 | 63.7 kb | Distal (>10kb) Multiome | 167 | |
| chr4:139,082,831–139,084,775 | 1.3 kb | Proximal (<10kb) Multiome | 1056 | |
| chr4:139,159,062–139,160,313 | 75.4 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 93.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 195.9 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 211.4 kb | Distal (>10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 217.0 kb | Distal (>10kb) Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 369.5 kb | Distal (>10kb) Multiome | 989 |
Genomic view of the ELF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.