ZNF582

zinc finger protein 582 | FLJ30927

The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Biological processes 8 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF582 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF582. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF582 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF582

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF582, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:56,120,040–56,122,160	272.1 kb	Distal (>10kb) Multiome	1006
chr19:56,140,231–56,141,860	252.5 kb	Distal (>10kb) Multiome	744
chr19:56,314,052–56,315,623	78.5 kb	Distal (>10kb) Multiome	844
chr19:56,346,962–56,347,557	46.2 kb	Distal (>10kb) Multiome	97
chr19:56,367,790–56,368,666	25.3 kb	Distal (>10kb) Multiome	609
chr19:56,393,166–56,393,951	24 bp	At TSS Multiome	653
chr19:56,403,714–56,404,765	10.6 kb	Distal (>10kb) Multiome	745
chr19:56,566,944–56,568,046	174.0 kb	Distal (>10kb) Multiome	436
chr19:56,594,882–56,595,857	201.8 kb	Distal (>10kb) Multiome	635
chr19:57,614,049–57,614,534	1220.7 kb	Distal (>10kb) Multiome HiCAR	661

Genome Browser

Genomic view of the ZNF582 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.