Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF350. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF350 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF350, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:51,687,813–51,691,477 | 295.7 kb | Distal (>10kb) Multiome | 820 | |
| chr19:51,702,162–51,704,690 | 282.6 kb | Distal (>10kb) Multiome | 758 | |
| chr19:51,904,568–51,905,180 | 81.9 kb | Distal (>10kb) Multiome | 662 | |
| chr19:51,926,700–51,927,523 | 59.7 kb | Distal (>10kb) Multiome | 675 | |
| chr19:51,986,785–51,987,050 | at TSS | At TSS | 651 | |
| chr19:52,007,532–52,008,736 | 21.4 kb | Distal (>10kb) Multiome | 704 | |
| chr19:52,027,979–52,028,972 | 41.7 kb | Distal (>10kb) Multiome | 837 | |
| chr19:52,048,367–52,049,488 | 62.1 kb | Distal (>10kb) Multiome | 711 | |
| chr19:52,139,087–52,140,222 | 153.2 kb | Distal (>10kb) Multiome | 788 | |
| chr19:52,170,935–52,172,031 | 184.8 kb | Distal (>10kb) Multiome | 404 | |
| chr19:52,189,175–52,190,788 | 203.1 kb | Distal (>10kb) Multiome | 912 | |
| chr19:52,269,012–52,270,193 | 282.7 kb | Distal (>10kb) Multiome | 782 |
Genomic view of the ZNF350 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.