This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for IGSF21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:17,909,687–17,910,396 | 197.9 kb | Distal (>10kb) Multiome HiCAR | 68 | |
| chr1:17,910,528–17,911,014 | 196.9 kb | Distal (>10kb) Multiome HiCAR | 37 | |
| chr1:18,090,558–18,091,301 | 16.9 kb | Distal (>10kb) Multiome | 112 | |
| chr1:18,099,020–18,099,373 | 8.4 kb | Proximal (<10kb) | 14 | |
| chr1:18,107,367–18,108,439 | 4 bp | At TSS Multiome | 181 | |
| chr1:18,109,790–18,110,886 | 2.6 kb | Proximal (<10kb) Multiome | 224 | |
| chr1:18,176,108–18,176,904 | 68.8 kb | Distal (>10kb) Multiome | 59 | |
| chr1:18,199,209–18,200,585 | 92.0 kb | Distal (>10kb) Multiome | 145 |
Genomic view of the IGSF21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.