chr8 : 109,686,138 109,686,287
149 bp 107 TFs 1 linked gene
This 149 bp open chromatin element is linked to SYBU and is bound by 107 transcription factors.
Linked Genes
1 gene
Gene Expression Dist. to TSS Distance Link type
SYBU 5.5 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr8:109,681,138 – 109,691,287
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
107 transcription factors
Source
Cell type
AFF1 3 datasets
ChIP K-562 ENCSR426URK.AFF1.K-562 149 bp overlap
ChIP K562 ENCFF583EEH 149 bp overlap
ChIP SEM_CX4945 GSE90762.AFF1.SEM_CX4945 149 bp overlap
AR 2 datasets
ChIP A-375 GSE116189.AR.A-375 149 bp overlap
ChIP A-375_SLNCR GSE116189.AR.A-375_SLNCR 149 bp overlap
ARID2 1 dataset
ChIP BIN-67_lentivirus-SMARCA4 GSE117734.ARID2.BIN-67_lentivirus-SMARCA4 149 bp overlap
ATF2 3 datasets
Motif DE_12h DE_12h-ATF2_MA1632.2 10 bp overlap
Motif ES_0h ES_0h-ATF2_MA1632.2 10 bp overlap
ChIP WA01 ENCSR000BQU.ATF2.WA01 149 bp overlap
Arid3a 1 dataset
Motif ES_0h ES_0h-Arid3a_MA0151.1 6 bp overlap
BCL11A 1 dataset
ChIP HUDEP-2_90min GSE104676.BCL11A.HUDEP-2_90min 60 bp overlap
BRD2 1 dataset
ChIP SUM159PT_JQ1 GSE116879.BRD2.SUM159PT_JQ1 110 bp overlap
BRD3 1 dataset
ChIP THP-1_DMSO-PMA GSE138084.BRD3.THP-1_DMSO-PMA 149 bp overlap
BRD4 1 dataset
ChIP MV4-11_IBET GSE71776.BRD4.MV4-11_IBET 149 bp overlap
BRD7 1 dataset
ChIP SUM159PT_JQ1 GSE131097.BRD7.SUM159PT_JQ1 140 bp overlap
CREB1 5 datasets
Motif DE_12h DE_12h-CREB1_MA0018.5 8 bp overlap
Motif ES_0h ES_0h-CREB1_MA0018.5 8 bp overlap
ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 136 bp overlap
ChIP LNCaP-abl_SHFOXA1 GSE63034.CREB1.LNCaP-abl_SHFOXA1 149 bp overlap
ChIP WA01 ENCSR000BSN.CREB1.WA01 123 bp overlap
CREM 2 datasets
Motif DE_12h DE_12h-CREM_MA0609.3 10 bp overlap
Motif ES_0h ES_0h-CREM_MA0609.3 10 bp overlap
DDX20 1 dataset
ChIP K-562 ENCSR382AIB.DDX20.K-562 116 bp overlap
E2F4 1 dataset
ChIP Hep-G2 ENCSR924LSO.E2F4.Hep-G2 128 bp overlap
EBF1 1 dataset
ChIP MUTUL GSE75503.EBF1.MUTUL 117 bp overlap
EGR1 1 dataset
ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 149 bp overlap
EHF 1 dataset
Motif ES_0h ES_0h-EHF_MA0598.4 9 bp overlap
EHMT2 6 datasets
ChIP A-549 ENCSR321BJQ.EHMT2.A-549 149 bp overlap
ChIP A549 ENCFF026GWM 149 bp overlap
ChIP HepG2 ENCFF004KYI 149 bp overlap
ChIP HepG2 ENCFF004KYI 149 bp overlap
ChIP K-562 ENCSR175EOM.EHMT2.K-562 149 bp overlap
ChIP K562 ENCFF053BWO 149 bp overlap
ELF1 1 dataset
Motif ES_0h ES_0h-ELF1_MA0473.4 9 bp overlap
ELF3 1 dataset
Motif ES_0h ES_0h-ELF3_MA0640.3 9 bp overlap
ELK4 1 dataset
Motif ES_0h ES_0h-ELK4_MA0076.3 9 bp overlap
EP300 1 dataset
ChIP AML GSE131939.EP300.AML 100 bp overlap
ERF 1 dataset
Motif ES_0h ES_0h-ERF_MA0760.2 9 bp overlap
ERG 1 dataset
ChIP aortic-endothelial-cell_D40 GSE139377.ERG.aortic-endothelial-cell_D40 97 bp overlap
ESR1 1 dataset
ChIP MCF-7_D538G_DMSO GSE148277.ESR1.MCF-7_D538G_DMSO 149 bp overlap
ETS1 1 dataset
Motif ES_0h ES_0h-ETS1_MA0098.4 9 bp overlap
ETV1 1 dataset
Motif ES_0h ES_0h-ETV1_MA0761.3 9 bp overlap
ETV2 1 dataset
Motif ES_0h ES_0h-ETV2_MA0762.2 9 bp overlap
Erg 1 dataset
Motif ES_0h ES_0h-Erg_MA0474.4 10 bp overlap
FLI1 1 dataset
Motif ES_0h ES_0h-FLI1_MA0475.3 9 bp overlap
FOS::JUN 2 datasets
Motif DE_12h DE_12h-FOSJUN_MA1126.2 10 bp overlap
Motif ES_0h ES_0h-FOSJUN_MA1126.2 10 bp overlap
FOSL2::JUN 2 datasets
Motif DE_12h DE_12h-FOSL2JUN_MA1131.2 10 bp overlap
Motif ES_0h ES_0h-FOSL2JUN_MA1131.2 10 bp overlap
FOSL2::JUND 2 datasets
Motif DE_12h DE_12h-FOSL2JUND_MA1145.2 10 bp overlap
Motif ES_0h ES_0h-FOSL2JUND_MA1145.2 10 bp overlap
FOXA1 12 datasets
ChIP 22Rv1_CST GSE123618.FOXA1.22Rv1_CST 149 bp overlap
ChIP 22Rv1_CST GSE129951.FOXA1.22Rv1_CST 123 bp overlap
ChIP 22Rv1_CST_Crispr-36 GSE123618.FOXA1.22Rv1_CST_Crispr-36 60 bp overlap
ChIP 22Rv1_CST_Crispr_WT3 GSE123618.FOXA1.22Rv1_CST_Crispr_WT3 148 bp overlap
ChIP 22Rv1_EtOH GSE80742.FOXA1.22Rv1_EtOH 148 bp overlap
ChIP 22Rv1_R1881 GSE80742.FOXA1.22Rv1_R1881 66 bp overlap
ChIP 22Rv1_TFS_Crispr_WT3 GSE123618.FOXA1.22Rv1_TFS_Crispr_WT3 80 bp overlap
ChIP 22Rv1_i176m_CST GSE123618.FOXA1.22Rv1_i176m_CST 99 bp overlap
ChIP MCF-7 ENCFF465LTH 149 bp overlap
ChIP MCF-7 ENCSR126YEB.FOXA1.MCF-7 92 bp overlap
ChIP VCaP_ETOH24H GSE58428.FOXA1.VCaP_ETOH24H 149 bp overlap
ChIP breast_tumor_Male_1 GSE104399.FOXA1.breast_tumor_Male_1 104 bp overlap
FOXA2 1 dataset
ChIP Caco-2 GSE66218.FOXA2.Caco-2 63 bp overlap
GABPA 1 dataset
Motif ES_0h ES_0h-GABPA_MA0062.4 10 bp overlap
HDAC1 1 dataset
ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.HDAC1.MCF-7_parental_4-hydroxytamoxifen 149 bp overlap
HNF1A 1 dataset
Motif ES_0h ES_0h-HNF1A_MA0046.3 13 bp overlap
HOXB13 1 dataset
ChIP prostate_P7_T GSE130408.HOXB13.prostate_P7_T 98 bp overlap
HOXB8 1 dataset
ChIP CFPAC-1_HOXB8-OE GSE119930.HOXB8.CFPAC-1_HOXB8-OE 149 bp overlap
HOXC6 1 dataset
ChIP 22Rv1 GSE129951.HOXC6.22Rv1 149 bp overlap
Hmga1 1 dataset
Motif ES_0h ES_0h-Hmga1_MA2124.1 8 bp overlap
Hnf1A 1 dataset
Motif ES_0h ES_0h-Hnf1A_MA1991.2 10 bp overlap
IKZF1 1 dataset
Motif ES_0h ES_0h-IKZF1_MA1508.2 8 bp overlap
IKZF2 2 datasets
Motif DE_12h DE_12h-IKZF2_MA2326.1 6 bp overlap
Motif ES_0h ES_0h-IKZF2_MA2326.1 6 bp overlap
Ikzf3 1 dataset
Motif ES_0h ES_0h-Ikzf3_MA1992.2 9 bp overlap
JUN 2 datasets
Motif DE_12h DE_12h-JUN_MA0488.2 10 bp overlap
Motif ES_0h ES_0h-JUN_MA0488.2 10 bp overlap
JUND 3 datasets
Motif DE_12h DE_12h-JUND_MA0492.2 11 bp overlap
Motif ES_0h ES_0h-JUND_MA0492.2 11 bp overlap
ChIP WA01 ENCSR000EBZ.JUND.WA01 143 bp overlap
KLF9 1 dataset
ChIP GBM1A GSE62211.KLF9.GBM1A 102 bp overlap
LIN54 1 dataset
Motif ES_0h ES_0h-LIN54_MA0619.2 7 bp overlap
Lef1 1 dataset
Motif ES_0h ES_0h-Lef1_MA0768.3 8 bp overlap
MAZ 1 dataset
ChIP K-562 ENCSR163IUV.MAZ.K-562 126 bp overlap
MEF2A 1 dataset
ChIP Hep-G2 ENCSR291MJH.MEF2A.Hep-G2 140 bp overlap
MIER1 2 datasets
ChIP K-562 ENCSR426MDV.MIER1.K-562 149 bp overlap
ChIP K562 ENCFF584AYC 149 bp overlap
MIER2 1 dataset
ChIP HepG2 ENCFF997QIX 149 bp overlap
MLLT1 1 dataset
ChIP MOLM-13 GSE82116.MLLT1.MOLM-13 149 bp overlap
MYBL2 1 dataset
ChIP Hep-G2 ENCSR581KCO.MYBL2.Hep-G2 114 bp overlap
MYCN 1 dataset
ChIP LNCaP_EtOH GSE117304.MYCN.LNCaP_EtOH 149 bp overlap
NR2C1 2 datasets
Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap
Motif ES_0h ES_0h-NR2C1_MA1535.2 6 bp overlap
NR2C2 2 datasets
Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap
Motif ES_0h ES_0h-NR2C2_MA1536.2 6 bp overlap
Nr1H2 2 datasets
Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap
Motif ES_0h ES_0h-Nr1H2_MA1996.2 6 bp overlap
Nr1H4 2 datasets
Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap
Motif ES_0h ES_0h-Nr1H4_MA1110.3 6 bp overlap
Nr1h3 2 datasets
Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap
Motif ES_0h ES_0h-Nr1h3_MA2337.1 6 bp overlap
PBX3 1 dataset
Motif ES_0h ES_0h-PBX3_MA1114.2 11 bp overlap
POU5F1 1 dataset
ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 73 bp overlap
REST 73 datasets
ChIP A-549 ENCSR000BQP.REST.A-549 149 bp overlap
ChIP A549 ENCFF148AIS 149 bp overlap
ChIP CD4 GSE49570.REST.CD4 149 bp overlap
Motif DE_12h DE_12h-REST_MA0138.3 20 bp overlap
Motif ES_0h ES_0h-REST_MA0138.3 20 bp overlap
ChIP GM12878 ENCFF235NGC 149 bp overlap
ChIP GM12878 ENCFF943QPB 149 bp overlap
ChIP GM12878 ENCSR000BQS.REST.GM12878 149 bp overlap
ChIP GM12878 ENCSR000BGF.REST.GM12878 149 bp overlap
ChIP GM23338 ENCFF024TCL 149 bp overlap
ChIP GM23338 ENCSR871KYB.REST.GM23338 149 bp overlap
ChIP GP5D GSE51234.REST.GP5D 149 bp overlap
ChIP GP5D_SIRAD21 GSE51234.REST.GP5D_SIRAD21 149 bp overlap
ChIP H1 ENCFF203SWY 149 bp overlap
ChIP H1 ENCFF429RUE 149 bp overlap
ChIP HCT-116 ENCSR000BVI.REST.HCT-116 149 bp overlap
ChIP HCT116 ENCFF929AYY 149 bp overlap
ChIP HEK293 ENCFF073DOT 149 bp overlap
ChIP HEK293 ENCSR896UBV.REST.HEK293 149 bp overlap
ChIP HL-60 ENCFF589LOF 149 bp overlap
ChIP HL-60 ENCSR000BTF.REST.HL-60 149 bp overlap
ChIP HeLa-S3 ENCFF911DTC 149 bp overlap
ChIP HeLa-S3 ENCSR000BMN.REST.HeLa-S3 149 bp overlap
ChIP Hep-G2 ENCSR000BOT.REST.Hep-G2 149 bp overlap
ChIP Hep-G2 ENCSR000BJL.REST.Hep-G2 149 bp overlap
ChIP HepG2 ENCFF122AWR 149 bp overlap
ChIP HepG2 ENCFF800JSL 149 bp overlap
ChIP Ishikawa ENCFF456OHV 149 bp overlap
ChIP Ishikawa ENCSR000BUU.REST.Ishikawa 149 bp overlap
ChIP K-562 ENCSR137ZMQ.REST.K-562 149 bp overlap
ChIP K-562 GSE70482.REST.K-562 149 bp overlap
ChIP K-562 ENCSR000BMW.REST.K-562 149 bp overlap
ChIP K562 ENCFF430APM 149 bp overlap
ChIP K562 ENCFF685YZN 149 bp overlap
ChIP K562 ENCFF688UKW 149 bp overlap
ChIP K562 ENCFF758CZL 149 bp overlap
ChIP MCF-7 ENCFF893RRD 149 bp overlap
ChIP MCF-7 ENCSR000BSP.REST.MCF-7 149 bp overlap
ChIP NCI-H295R GSE49014.REST.NCI-H295R 149 bp overlap
ChIP NCI-H295R_SF1 GSE49014.REST.NCI-H295R_SF1 149 bp overlap
ChIP PANC-1 ENCSR000BUP.REST.PANC-1 149 bp overlap
ChIP PANC-1 ENCSR000BPK.REST.PANC-1 149 bp overlap
ChIP PANC-1 ENCSR000BJO.REST.PANC-1 149 bp overlap
ChIP PFSK-1 ENCFF668WMP 149 bp overlap
ChIP PFSK-1 ENCFF845VHA 149 bp overlap
ChIP PFSK1 ENCSR000BJP.REST.PFSK1 149 bp overlap
ChIP PFSK1 ENCSR000BOX.REST.PFSK1 149 bp overlap
ChIP Panc1 ENCFF338WSQ 149 bp overlap
ChIP Panc1 ENCFF518EEQ 149 bp overlap
ChIP Panc1 ENCFF629OJO 149 bp overlap
ChIP SK-N-SH ENCFF635KBN 149 bp overlap
ChIP SK-N-SH ENCFF861MKH 149 bp overlap
ChIP SK-N-SH ENCSR000BJJ.REST.SK-N-SH 149 bp overlap
ChIP WA01 ENCSR663WAR.REST.WA01 149 bp overlap
ChIP WA01 ENCSR000BHM.REST.WA01 149 bp overlap
ChIP colorectal-cancer_CRC121_dissociated GSE112555.REST.colorectal-cancer_CRC121_dissociated 149 bp overlap
ChIP colorectal-cancer_CRC121_intact GSE112555.REST.colorectal-cancer_CRC121_intact 149 bp overlap
ChIP colorectal-cancer_shCDH1 GSE112555.REST.colorectal-cancer_shCDH1 149 bp overlap
ChIP colorectal-cancer_shCTRL_dissociated GSE112555.REST.colorectal-cancer_shCTRL_dissociated 149 bp overlap
ChIP colorectal-cancer_shCTRL_intact GSE112555.REST.colorectal-cancer_shCTRL_intact 149 bp overlap
ChIP hepatocyte ERP000395.REST.hepatocyte 149 bp overlap
ChIP hiPSC_IA12 GSE106870.REST.hiPSC_IA12 149 bp overlap
ChIP hiPSC_IB12 GSE106870.REST.hiPSC_IB12 149 bp overlap
ChIP hiPSC_IIA11 GSE106870.REST.hiPSC_IIA11 149 bp overlap
ChIP hiPSC_IID12 GSE106870.REST.hiPSC_IID12 149 bp overlap
ChIP liver ENCFF240FWT 149 bp overlap
ChIP liver ENCFF577AZT 149 bp overlap
ChIP liver ENCSR893QWP.REST.liver 149 bp overlap
ChIP liver ENCSR867WPH.REST.liver 149 bp overlap
ChIP metastatic-neuroblastoma_CHLA90 GSE100148.REST.metastatic-neuroblastoma_CHLA90 149 bp overlap
ChIP metastatic-neuroblastoma_SKNMM GSE100148.REST.metastatic-neuroblastoma_SKNMM 149 bp overlap
ChIP neural ENCSR000BTV.REST.neural 148 bp overlap
ChIP neural cell ENCFF882LXX 149 bp overlap
RXRA 1 dataset
ChIP WA01 ENCSR000BJW.RXRA.WA01 136 bp overlap
SIN3A 1 dataset
ChIP WA01 ENCSR000EBO.SIN3A.WA01 129 bp overlap
SMAD3 1 dataset
ChIP Hep-G2 ENCSR005GZH.SMAD3.Hep-G2 134 bp overlap
SMARCA4 7 datasets
ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 149 bp overlap
ChIP MCF-7 GSE123284.SMARCA4.MCF-7 149 bp overlap
ChIP MCF-7_parental GSE123284.SMARCA4.MCF-7_parental 149 bp overlap
ChIP NPC_siSOX GSE122631.SMARCA4.NPC_siSOX 139 bp overlap
ChIP TTC-1240_R377H GSE124903.SMARCA4.TTC-1240_R377H 149 bp overlap
ChIP hiPSC GSE124903.SMARCA4.hiPSC 149 bp overlap
ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 149 bp overlap
SMARCB1 7 datasets
ChIP MCF-7 GSE123284.SMARCB1.MCF-7 149 bp overlap
ChIP MCF-7_4-hydroxytamoxifen GSE123284.SMARCB1.MCF-7_4-hydroxytamoxifen 138 bp overlap
ChIP MCF-7_DCDT GSE123284.SMARCB1.MCF-7_DCDT 124 bp overlap
ChIP MCF-7_Fulvestrant GSE123284.SMARCB1.MCF-7_Fulvestrant 147 bp overlap
ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 149 bp overlap
ChIP hiPSC GSE124903.SMARCB1.hiPSC 149 bp overlap
ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 149 bp overlap
SMARCC1 6 datasets
ChIP SK-N-MC GSE94275.SMARCC1.SK-N-MC 149 bp overlap
ChIP SK-N-MC_shEWSFLI1 GSE94275.SMARCC1.SK-N-MC_shEWSFLI1 87 bp overlap
ChIP SK-N-MC_shGFP GSE94275.SMARCC1.SK-N-MC_shGFP 149 bp overlap
ChIP SYO-1_shCt GSE139053.SMARCC1.SYO-1_shCt 149 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 149 bp overlap
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 149 bp overlap
SMC3 3 datasets
ChIP HeLa GSE126990.SMC3.HeLa 126 bp overlap
ChIP HeLa-Kyoto GSE102884.SMC3.HeLa-Kyoto 126 bp overlap
ChIP HeLa-Kyoto GSE138405.SMC3.HeLa-Kyoto 126 bp overlap
SOX10 2 datasets
Motif DE_12h DE_12h-SOX10_MA0442.3 6 bp overlap
Motif ES_0h ES_0h-SOX10_MA0442.3 6 bp overlap
SPDEF 1 dataset
ChIP MCF-7 ENCSR042GSX.SPDEF.MCF-7 146 bp overlap
SPI1 2 datasets
ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 149 bp overlap
ChIP EM-3 GSE128834.SPI1.EM-3 137 bp overlap
SPIB 2 datasets
Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap
Motif ES_0h ES_0h-SPIB_MA0081.3 13 bp overlap
Sox11 2 datasets
Motif DE_12h DE_12h-Sox11_MA0869.3 8 bp overlap
Motif ES_0h ES_0h-Sox11_MA0869.3 8 bp overlap
Spi1 2 datasets
Motif DE_12h DE_12h-Spi1_MA0080.7 13 bp overlap
Motif ES_0h ES_0h-Spi1_MA0080.7 13 bp overlap
TCF7 1 dataset
Motif ES_0h ES_0h-TCF7_MA0769.3 7 bp overlap
TEAD4 2 datasets
ChIP A-549 ENCSR000BUD.TEAD4.A-549 149 bp overlap
ChIP A549 ENCFF243FTL 149 bp overlap
TFE3 1 dataset
ChIP Hep-G2 ENCSR589SNT.TFE3.Hep-G2 149 bp overlap
THRB 2 datasets
Motif DE_12h DE_12h-THRB_MA1576.2 18 bp overlap
Motif ES_0h ES_0h-THRB_MA1576.2 18 bp overlap
TLE3 2 datasets
ChIP 22Rv1_WT3_Crispr GSE123618.TLE3.22Rv1_WT3_Crispr 80 bp overlap
ChIP LNCaP GSE94682.TLE3.LNCaP 70 bp overlap
VEZF1 2 datasets
Motif DE_12h DE_12h-VEZF1_MA1578.2 6 bp overlap
Motif ES_0h ES_0h-VEZF1_MA1578.2 6 bp overlap
ZBTB24 1 dataset
ChIP HCT-116 GSE111683.ZBTB24.HCT-116 149 bp overlap
ZFP14 1 dataset
Motif ES_0h ES_0h-ZFP14_MA1972.1 15 bp overlap
ZFP37 1 dataset
ChIP Hep-G2 ENCSR505LJT.ZFP37.Hep-G2 118 bp overlap
ZGPAT 1 dataset
ChIP Hep-G2 ENCSR704IGU.ZGPAT.Hep-G2 149 bp overlap
ZNF12 1 dataset
ChIP Hep-G2 ENCSR711KBM.ZNF12.Hep-G2 113 bp overlap
ZNF143 3 datasets
ChIP Hep-G2 ENCSR101FJT.ZNF143.Hep-G2 103 bp overlap
ChIP MCF-7 GSE76454.ZNF143.MCF-7 131 bp overlap
ChIP WA01 ENCSR000EBW.ZNF143.WA01 131 bp overlap
ZNF16 1 dataset
Motif ES_0h ES_0h-ZNF16_MA1654.2 21 bp overlap
ZNF175 1 dataset
Motif ES_0h ES_0h-ZNF175_MA2332.1 9 bp overlap
ZNF384 2 datasets
ChIP Hep-G2 ENCSR101FJU.ZNF384.Hep-G2 125 bp overlap
ChIP HepG2 ENCFF129PLC 149 bp overlap