Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF311. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF311 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF311, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:28,709,835–28,710,861 | 295.2 kb | Distal (>10kb) Multiome | 486 | |
| chr6:28,758,091–28,758,572 | 247.0 kb | Distal (>10kb) Multiome | 538 | |
| chr6:28,766,057–28,766,737 | 238.8 kb | Distal (>10kb) Multiome | 45 | |
| chr6:28,775,686–28,777,151 | 228.8 kb | Distal (>10kb) Multiome | 330 | |
| chr6:28,789,668–28,790,123 | 215.5 kb | Distal (>10kb) Multiome | 466 | |
| chr6:28,795,706–28,796,323 | 209.2 kb | Distal (>10kb) Multiome | 598 | |
| chr6:28,837,417–28,839,268 | 166.4 kb | Distal (>10kb) Multiome | 927 | |
| chr6:28,863,417–28,864,476 | 141.4 kb | Distal (>10kb) Multiome | 894 | |
| chr6:28,865,612–28,867,050 | 139.0 kb | Distal (>10kb) Multiome | 785 | |
| chr6:28,895,454–28,897,321 | 109.1 kb | Distal (>10kb) Multiome | 1132 | |
| chr6:28,923,043–28,924,600 | 81.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr6:28,940,313–28,941,870 | 64.5 kb | Distal (>10kb) Multiome | 807 | |
| chr6:28,943,542–28,944,680 | 61.6 kb | Distal (>10kb) Multiome | 783 | |
| chr6:28,980,730–28,982,814 | 23.0 kb | Distal (>10kb) Multiome | 914 | |
| chr6:28,984,693–28,985,963 | 19.7 kb | Distal (>10kb) Multiome | 553 | |
| chr6:28,988,531–28,989,268 | 16.5 kb | Distal (>10kb) Multiome | 290 | |
| chr6:29,005,579–29,005,760 | 263 bp | At TSS | 269 | |
| chr6:29,014,571–29,016,258 | 9.6 kb | Proximal (<10kb) Multiome | 293 | |
| chr6:29,016,579–29,017,058 | 11.7 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the ZNF311 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.