This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for ZFP37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:112,771,981–112,772,634 | 284.5 kb | Distal (>10kb) Multiome | 89 | |
| chr9:113,011,893–113,012,348 | 44.6 kb | Distal (>10kb) Multiome | 444 | |
| chr9:113,056,219–113,057,065 | 7 bp | At TSS Multiome | 732 | |
| chr9:113,150,622–113,151,556 | 94.3 kb | Distal (>10kb) Multiome | 705 | |
| chr9:113,220,980–113,222,241 | 164.7 kb | Distal (>10kb) Multiome | 819 | |
| chr9:113,274,845–113,275,974 | 218.8 kb | Distal (>10kb) Multiome | 852 | |
| chr9:113,331,229–113,332,031 | 275.0 kb | Distal (>10kb) Multiome | 69 | |
| chr9:113,339,770–113,340,691 | 283.5 kb | Distal (>10kb) Multiome | 941 | |
| chr9:113,349,409–113,349,994 | 292.9 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the ZFP37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.