HNF1A
HNF1 homeobox A | HNF1, HNF1α, LFB1, MODY3, TCF1

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Biological processes 68 terms
D-glucose import across plasma membrane (GO:0098708)D-glucose import across plasma membrane (GO:0098708)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)apoptotic nuclear changes (GO:0030262)cellular response to L-leucine (GO:0071233)cellular response to glucose stimulus (GO:0071333)cellular response to rapamycin (GO:0072752)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)double-stranded DNA binding (GO:0003690)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)identical protein binding (GO:0042802)insulin secretion (GO:0030073)insulin secretion (GO:0030073)liver development (GO:0001889)negative regulation of apoptotic process (GO:0043066)negative regulation of miRNA processing (GO:1903799)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)pancreas development (GO:0031016)photoreceptor outer segment (GO:0001750)positive regulation of ATP biosynthetic process (GO:2001171)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of gene expression (GO:0010628)positive regulation of insulin secretion (GO:0032024)positive regulation of mitochondrial membrane potential (GO:0010918)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)pronucleus (GO:0045120)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein dimerization activity (GO:0046983)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)regulation of NADP metabolic process (GO:1902031)regulation of pronephros size (GO:0035565)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)renal D-glucose absorption (GO:0035623)renal D-glucose absorption (GO:0035623)sequence-specific DNA binding (GO:0043565)transcription by RNA polymerase II (GO:0006366)transcription cis-regulatory region binding (GO:0000976)transcription coactivator binding (GO:0001223)transcription coregulator binding (GO:0001221)transcription regulator complex (GO:0005667)
Expression (TPM)
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