This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for MIER1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIER1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIER1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:65,002,269–65,003,167 | 1922.2 kb | Distal (>10kb) Multiome HiCAR | 584 | |
| chr1:65,147,108–65,150,062 | 1775.7 kb | Distal (>10kb) Multiome HiCAR | 912 | |
| chr1:66,751,604–66,753,218 | 172.5 kb | Distal (>10kb) Multiome | 318 | |
| chr1:66,916,371–66,916,586 | 8.4 kb | Proximal (<10kb) | 189 | |
| chr1:66,923,845–66,926,268 | 220 bp | At TSS Multiome | 945 | |
| chr1:66,929,624–66,931,089 | 5.3 kb | Proximal (<10kb) Multiome | 922 | |
| chr1:67,053,062–67,054,800 | 128.7 kb | Distal (>10kb) Multiome | 993 |
Genomic view of the MIER1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.