This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,447,046–6,448,661 | 258.9 kb | Distal (>10kb) Multiome | 944 | |
| chr7:6,483,337–6,484,560 | 222.7 kb | Distal (>10kb) Multiome | 748 | |
| chr7:6,502,814–6,505,187 | 202.8 kb | Distal (>10kb) Multiome | 573 | |
| chr7:6,516,399–6,516,954 | 190.3 kb | Distal (>10kb) Multiome | 245 | |
| chr7:6,526,260–6,527,132 | 180.2 kb | Distal (>10kb) Multiome | 313 | |
| chr7:6,530,620–6,531,774 | 175.7 kb | Distal (>10kb) Multiome | 296 | |
| chr7:6,536,237–6,537,265 | 170.0 kb | Distal (>10kb) Multiome | 223 | |
| chr7:6,577,282–6,577,787 | 129.4 kb | Distal (>10kb) Multiome | 840 | |
| chr7:6,589,551–6,590,781 | 116.9 kb | Distal (>10kb) Multiome | 802 | |
| chr7:6,614,875–6,616,376 | 91.5 kb | Distal (>10kb) Multiome | 610 | |
| chr7:6,640,237–6,641,084 | 66.3 kb | Distal (>10kb) Multiome | 238 | |
| chr7:6,663,809–6,664,686 | 42.9 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,706,296–6,707,347 | 25 bp | At TSS Multiome | 718 | |
| chr7:6,729,225–6,730,453 | 22.8 kb | Distal (>10kb) Multiome | 755 | |
| chr7:6,901,511–6,903,145 | 195.5 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,995,280–6,995,919 | 288.7 kb | Distal (>10kb) Multiome | 100 |
Genomic view of the ZNF12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.