The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SMARCD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMARCD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMARCD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:149,713,614–149,715,757 | 1533.9 kb | Distal (>10kb) Multiome HiCAR | 639 | |
| chr7:150,973,967–150,975,352 | 273.9 kb | Distal (>10kb) Multiome | 572 | |
| chr7:150,977,414–150,979,693 | 270.3 kb | Distal (>10kb) Multiome | 629 | |
| chr7:150,988,543–150,989,168 | 259.9 kb | Distal (>10kb) Multiome | 348 | |
| chr7:151,007,679–151,009,192 | 240.0 kb | Distal (>10kb) Multiome | 693 | |
| chr7:151,012,895–151,014,461 | 234.8 kb | Distal (>10kb) Multiome | 414 | |
| chr7:151,017,863–151,019,302 | 230.3 kb | Distal (>10kb) Multiome | 677 | |
| chr7:151,026,724–151,029,117 | 220.2 kb | Distal (>10kb) Multiome | 1003 | |
| chr7:151,050,894–151,051,476 | 197.4 kb | Distal (>10kb) Multiome | 289 | |
| chr7:151,057,294–151,063,500 | 189.0 kb | Distal (>10kb) Multiome | 1138 | |
| chr7:151,080,217–151,081,897 | 167.8 kb | Distal (>10kb) Multiome | 909 | |
| chr7:151,083,053–151,083,998 | 165.2 kb | Distal (>10kb) Multiome | 581 | |
| chr7:151,085,505–151,086,758 | 162.5 kb | Distal (>10kb) Multiome | 774 | |
| chr7:151,110,933–151,111,501 | 137.5 kb | Distal (>10kb) Multiome | 365 | |
| chr7:151,114,416–151,115,951 | 133.2 kb | Distal (>10kb) Multiome | 279 | |
| chr7:151,123,775–151,124,402 | 124.6 kb | Distal (>10kb) Multiome | 399 | |
| chr7:151,125,352–151,126,446 | 122.8 kb | Distal (>10kb) Multiome | 283 | |
| chr7:151,166,900–151,168,657 | 80.4 kb | Distal (>10kb) Multiome | 533 | |
| chr7:151,172,589–151,173,067 | 75.9 kb | Distal (>10kb) Multiome | 592 | |
| chr7:151,226,743–151,227,948 | 21.3 kb | Distal (>10kb) Multiome | 820 | |
| chr7:151,232,039–151,233,087 | 16.2 kb | Distal (>10kb) Multiome | 692 | |
| chr7:151,244,403–151,244,570 | 942 bp | At TSS | 144 | |
| chr7:151,244,849–151,245,940 | 3.1 kb | Proximal (<10kb) Multiome | 325 | |
| chr7:151,246,056–151,247,159 | 543 bp | At TSS | 205 | |
| chr7:151,247,809–151,249,951 | 113 bp | At TSS Multiome | 522 | |
| chr7:151,251,506–151,252,414 | 3.2 kb | Proximal (<10kb) Multiome | 448 | |
| chr7:151,259,810–151,260,360 | 11.4 kb | Distal (>10kb) Multiome | 135 | |
| chr7:151,275,718–151,276,602 | 27.6 kb | Distal (>10kb) Multiome | 99 | |
| chr7:151,276,919–151,277,487 | 28.5 kb | Distal (>10kb) Multiome | 367 | |
| chr7:151,303,363–151,304,005 | 55.0 kb | Distal (>10kb) Multiome HiCAR | 458 | |
| chr7:151,306,906–151,307,424 | 58.4 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr7:151,341,187–151,342,118 | 93.0 kb | Distal (>10kb) Multiome HiCAR | 757 | |
| chr7:151,408,879–151,410,989 | 161.4 kb | Distal (>10kb) Multiome | 407 | |
| chr7:151,439,682–151,441,031 | 191.4 kb | Distal (>10kb) Multiome | 189 | |
| chr7:151,448,171–151,448,932 | 200.0 kb | Distal (>10kb) Multiome | 403 | |
| chr7:151,519,052–151,521,056 | 271.4 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the SMARCD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.