This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for TLE3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLE3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLE3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:69,462,352–69,463,273 | 635.0 kb | Distal (>10kb) Multiome HiCAR | 753 | |
| chr15:69,594,118–69,595,443 | 503.1 kb | Distal (>10kb) Multiome HiCAR | 716 | |
| chr15:69,826,035–69,826,507 | 271.6 kb | Distal (>10kb) Multiome | 95 | |
| chr15:69,861,448–69,863,147 | 235.9 kb | Distal (>10kb) Multiome | 206 | |
| chr15:69,885,224–69,886,009 | 212.2 kb | Distal (>10kb) Multiome | 104 | |
| chr15:69,909,773–69,910,500 | 187.8 kb | Distal (>10kb) Multiome | 66 | |
| chr15:70,089,080–70,089,364 | 8.5 kb | Proximal (<10kb) | 157 | |
| chr15:70,091,993–70,092,625 | 5.7 kb | Proximal (<10kb) Multiome | 434 | |
| chr15:70,093,529–70,093,956 | 3.9 kb | Proximal (<10kb) | 279 | |
| chr15:70,095,372–70,099,977 | 1.8 kb | Proximal (<10kb) Multiome | 1130 | |
| chr15:70,100,144–70,101,374 | 2.3 kb | Proximal (<10kb) | 516 | |
| chr15:70,101,474–70,102,039 | 3.8 kb | Proximal (<10kb) Multiome | 448 | |
| chr15:70,111,239–70,112,014 | 13.7 kb | Distal (>10kb) Multiome | 452 | |
| chr15:70,159,730–70,160,541 | 62.3 kb | Distal (>10kb) Multiome | 106 | |
| chr15:70,171,340–70,172,450 | 73.9 kb | Distal (>10kb) Multiome | 210 | |
| chr15:70,309,816–70,310,301 | 212.1 kb | Distal (>10kb) Multiome | 84 | |
| chr15:70,315,471–70,315,909 | 217.8 kb | Distal (>10kb) Multiome | 16 | |
| chr15:70,344,359–70,344,961 | 246.7 kb | Distal (>10kb) Multiome | 91 |
Genomic view of the TLE3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.