This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for BRD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:50,152,387–50,154,528 | 215.8 kb | Distal (>10kb) Multiome | 930 | |
| chr16:50,368,327–50,369,672 | 102 bp | At TSS Multiome | 596 | |
| chr16:50,374,762–50,374,977 | 6.0 kb | Proximal (<10kb) | 303 | |
| chr16:50,467,766–50,468,772 | 99.3 kb | Distal (>10kb) Multiome | 685 | |
| chr16:50,539,882–50,540,391 | 171.2 kb | Distal (>10kb) Multiome HiCAR | 134 | |
| chr16:50,547,325–50,549,168 | 179.4 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr16:50,665,176–50,665,840 | 296.6 kb | Distal (>10kb) Multiome HiCAR | 469 |
Genomic view of the BRD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.