TCF7

transcription factor 7 | TCF-1

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

Member of: DE-6 Developmental clusters: GC3

Biological processes 25 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity (GO:0001217)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)Wnt signaling pathway (GO:0016055)beta-catenin binding (GO:0008013)beta-catenin-TCF complex (GO:1990907)canonical Wnt signaling pathway (GO:0060070)cellular response to interleukin-4 (GO:0071353)chromatin (GO:0000785)gamma-delta T cell differentiation (GO:0042492)immune response (GO:0006955)immune system process (GO:0002376)negative regulation of DNA-templated transcription (GO:0045892)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of gamma-delta T cell differentiation (GO:0045586)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating TCF7 0 TFs

Transcription factors with Perturb-seq knockdown data for TCF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TCF7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:133,968,103–133,968,907	146.0 kb	Distal (>10kb) Multiome	861
chr5:134,004,027–134,006,483	109.9 kb	Distal (>10kb) Multiome	948
chr5:134,039,553–134,040,013	74.9 kb	Distal (>10kb) Multiome HiCAR	576
chr5:134,070,573–134,071,963	43.4 kb	Distal (>10kb) Multiome	666
chr5:134,099,891–134,100,749	14.5 kb	Distal (>10kb) Multiome	227
chr5:134,101,617–134,102,291	12.6 kb	Distal (>10kb) Multiome	334
chr5:134,111,569–134,112,126	2.6 kb	Proximal (<10kb)	74
chr5:134,113,043–134,116,112	1.0 kb	Proximal (<10kb) Multiome	637
chr5:134,140,528–134,140,995	26.1 kb	Distal (>10kb) Multiome	342
chr5:134,176,142–134,177,562	62.3 kb	Distal (>10kb) Multiome	952
chr5:134,184,086–134,184,650	69.7 kb	Distal (>10kb) Multiome	289
chr5:134,225,248–134,227,248	111.6 kb	Distal (>10kb) Multiome	1043
chr5:134,366,722–134,367,362	252.5 kb	Distal (>10kb) Multiome	682
chr5:134,370,722–134,372,303	256.6 kb	Distal (>10kb) Multiome	1080
chr5:134,411,465–134,412,433	297.3 kb	Distal (>10kb) Multiome	989

Genome Browser

Genomic view of the TCF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.