chr22:17,272,506–17,273,119

chr22 : 17,272,506 – 17,273,119

613 bp 82 TFs 8 linked genes

This 613 bp open chromatin element is linked to 8 target genes and is bound by 82 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
CECR3		5.8 kb	Proximal	Proximity
ADA2		73.1 kb	Distal	Multiome
CECR2		96.7 kb	Distal	Multiome
HDHD5-AS1		113.4 kb	Distal	Multiome
HDHD5		113.5 kb	Distal	Multiome
IL17RA		187.8 kb	Distal	Multiome
ENSG00000290931		236.2 kb	Distal	Multiome
SLC25A18		290.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

82 transcription factors

ChIP LNCaP_L388M_shFOXA1_Ethanol GSE128883.AR.LNCaP_L388M_shFOXA1_Ethanol 150 bp overlap

ChIP MCF-7 GSE48930.AR.MCF-7 167 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 613 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 475 bp overlap

ASXL3 1 dataset

ChIP NCI-H1963_Ab1 GSE145028.ASXL3.NCI-H1963_Ab1 381 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 339 bp overlap

BRD4 5 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 575 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 496 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 561 bp overlap

ChIP SEM GSE83671.BRD4.SEM 208 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 486 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 123 bp overlap

ChIP macrophage GSE136216.CHD4.macrophage 399 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 213 bp overlap

CTCF 30 datasets

ChIP CD14-positive monocyte ENCFF087XLR 132 bp overlap

ChIP DOHH2 ENCFF637WNW 73 bp overlap

ChIP DOHH2 ENCSR084RDK.CTCF.DOHH2 105 bp overlap

ChIP GM04604 GSE148179.CTCF.GM04604 103 bp overlap

ChIP GM04648 GSE148179.CTCF.GM04648 117 bp overlap

ChIP GM23338 ENCFF531QOI 165 bp overlap

ChIP GM23338 ENCFF832KWE 203 bp overlap

ChIP HCT-116 ENCSR240PRQ.CTCF.HCT-116 192 bp overlap

ChIP HEK293 ENCSR000DTW.CTCF.HEK293 80 bp overlap

ChIP KARPAS422 ENCSR113REG.CTCF.KARPAS422 64 bp overlap

ChIP Loucy ENCSR464DKE.CTCF.Loucy 120 bp overlap

ChIP OCI-LY7 ENCFF086AXQ 89 bp overlap

ChIP OCI-Ly7 ENCSR027HML.CTCF.OCI-Ly7 68 bp overlap

ChIP PC-3 ENCSR359LOD.CTCF.PC-3 124 bp overlap

ChIP activated CD4-positive, alpha-beta T cell ENCFF095PZX 153 bp overlap

ChIP activated CD4-positive, alpha-beta T cell ENCFF095PZX 353 bp overlap

ChIP anterior-temporal-cortex_fetal GSE116825.CTCF.anterior-temporal-cortex_fetal 154 bp overlap

ChIP chondrocyte ENCFF134ORZ 82 bp overlap

ChIP chondrocyte ENCFF134ORZ 293 bp overlap

ChIP endothelial cell ENCFF663LIE 58 bp overlap

ChIP endothelial cell ENCFF663LIE 259 bp overlap

ChIP glutamatergic neuron ENCFF816BTR 56 bp overlap

ChIP glutamatergic neuron ENCFF816BTR 257 bp overlap

ChIP hESC_D5 GSE116862.CTCF.hESC_D5 145 bp overlap

ChIP leukemia GSE142161.CTCF.leukemia 146 bp overlap

ChIP lymphoblast_mut GSE155324.CTCF.lymphoblast_mut 471 bp overlap

ChIP mesothelial cell of epicardium ENCFF427RFE 218 bp overlap

ChIP nephron ENCFF972IQB 133 bp overlap

ChIP neural progenitor cell ENCFF581WPG 279 bp overlap

ChIP type B pancreatic cell ENCFF910FNQ 186 bp overlap

ChIP A-549 GSE122203.ELF1.A-549 152 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 231 bp overlap

ChIP SKNO-1 GSE23730.ERG.SKNO-1 219 bp overlap

ESR1 6 datasets

ChIP Ishikawa_E2-1h GSE129803.ESR1.Ishikawa_E2-1h 258 bp overlap

ChIP MCF-7_DMSO GSE125594.ESR1.MCF-7_DMSO 200 bp overlap

ChIP MCF-7_E2 ERP000209.ESR1.MCF-7_E2 127 bp overlap

ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 182 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 201 bp overlap

ChIP breast_tumor_Male_21 GSE104399.ESR1.breast_tumor_Male_21 249 bp overlap

ESR1_Y537S 1 dataset

ChIP MCF-7_E2 GSE94493.ESR1_Y537S.MCF-7_E2 172 bp overlap

ETS1 3 datasets

ChIP CTV-1_DSG GSE128835.ETS1.CTV-1_DSG 280 bp overlap

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 309 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 402 bp overlap

FLI1 2 datasets

ChIP CTV-1_DSG GSE128835.FLI1.CTV-1_DSG 235 bp overlap

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 285 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 236 bp overlap

ChIP DE DE-FOXA2-2 285 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 111 bp overlap

ChIP DE DE-GATA4-2 613 bp overlap

ChIP foregut GSE117136.GATA4.foregut 96 bp overlap

GATA6 10 datasets

ChIP AGS GSE51936.GATA6.AGS 107 bp overlap

ChIP DE DE-GATA6-1 153 bp overlap

ChIP DE DE-GATA6-2 438 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 306 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 319 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 517 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 187 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 60 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 379 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 613 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 177 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 208 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 503 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 326 bp overlap

HNF4A 1 dataset

ChIP hiPSC GSE104613.HNF4A.hiPSC 198 bp overlap

HNRNPLL 1 dataset

ChIP K-562 ENCSR112RNT.HNRNPLL.K-562 138 bp overlap

IKZF1 1 dataset

ChIP BCR-ABL1_LAX2 GSE58825.IKZF1.BCR-ABL1_LAX2 367 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 243 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 320 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 397 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 405 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 445 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 398 bp overlap

KDM6B 1 dataset

ChIP CUTLL1 GSE56694.KDM6B.CUTLL1 228 bp overlap

KLF17 2 datasets

ChIP HEK293 ENCFF658MHR 425 bp overlap

ChIP HEK293 ENCSR065WUF.KLF17.HEK293 367 bp overlap

KMT2A 1 dataset

ChIP RCH-ACV GSE83671.KMT2A.RCH-ACV 235 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 262 bp overlap

ChIP HEK293 GSE76494.MAZ.HEK293 273 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 275 bp overlap

MCRS1 1 dataset

ChIP Huh-7 GSE97411.MCRS1.Huh-7 287 bp overlap

MED1 2 datasets

ChIP HCT-116_shLuc GSE121798.MED1.HCT-116_shLuc 420 bp overlap

ChIP MM1-S_JQ1_50NM GSE49224.MED1.MM1-S_JQ1_50NM 166 bp overlap

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 198 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 205 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 459 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 327 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 400 bp overlap

NFE2L1 2 datasets

ChIP WTC11 ENCFF644BPU 348 bp overlap

ChIP WTC11 ENCFF644BPU 377 bp overlap

NFKB1 1 dataset

ChIP HEK293T GSE129618.NFKB1.HEK293T 295 bp overlap

NIPBL 1 dataset

ChIP WA09_heat-shock GSE105028.NIPBL.WA09_heat-shock 265 bp overlap

NR3C1 2 datasets

ChIP ALL_DEX GSE109946.NR3C1.ALL_DEX 166 bp overlap

ChIP SUP-B15_DEX GSE107584.NR3C1.SUP-B15_DEX 399 bp overlap

POLR2A 1 dataset

ChIP H1 ENCFF566JSR 611 bp overlap

POU5F1 4 datasets

ChIP BG03 GSE21614.POU5F1.BG03 189 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 441 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 244 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 264 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 284 bp overlap

RAD21 3 datasets

ChIP H1 ENCFF698EWO 241 bp overlap

ChIP WA09_heat-shock GSE105028.RAD21.WA09_heat-shock 302 bp overlap

ChIP hiPSC_CVI GSE106870.RAD21.hiPSC_CVI 127 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 284 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 458 bp overlap

ChIP WA01 ENCSR000BHM.REST.WA01 110 bp overlap

SIX2 2 datasets

ChIP HEK GSE73865.SIX2.HEK 225 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 53 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 364 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 613 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 360 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 208 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 310 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 418 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 302 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 59 bp overlap

SMARCA4 4 datasets

ChIP CTV-1_DSG GSE128835.SMARCA4.CTV-1_DSG 328 bp overlap

ChIP CTV-1_FLAG GSE128835.SMARCA4.CTV-1_FLAG 312 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 405 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 348 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 280 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 117 bp overlap

SMARCC1 3 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 292 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 161 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 243 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 266 bp overlap

ChIP HEK293 GSE76494.SP1.HEK293 255 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 250 bp overlap

ChIP liver ENCFF597LFJ 318 bp overlap

ChIP HEK293 GSE76494.SP2.HEK293 329 bp overlap

ChIP HEK293 GSE76494.SP4.HEK293 283 bp overlap

SPI1 15 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 213 bp overlap

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 373 bp overlap

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 304 bp overlap

ChIP DC_LPS GSE123347.SPI1.DC_LPS 172 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 341 bp overlap

ChIP Kasumi-1_SICTR GSE60130.SPI1.Kasumi-1_SICTR 148 bp overlap

ChIP NB4 GSE128834.SPI1.NB4 182 bp overlap

ChIP THP-1 GSE128834.SPI1.THP-1 90 bp overlap

ChIP THP-1_DIFF GSE25426.SPI1.THP-1_DIFF 207 bp overlap

ChIP macrophage_D7_donorP GSE128834.SPI1.macrophage_D7_donorP 285 bp overlap

ChIP monocyte GSE31621.SPI1.monocyte 189 bp overlap

ChIP monocyte_MACROPHAGE GSE31621.SPI1.monocyte_MACROPHAGE 201 bp overlap

ChIP primary-monocyte_18h_donorO GSE128834.SPI1.primary-monocyte_18h_donorO 251 bp overlap

ChIP primary-monocyte_4h_donorO GSE128834.SPI1.primary-monocyte_4h_donorO 154 bp overlap

ChIP primary-monocyte_donorA_ncMO GSE128834.SPI1.primary-monocyte_donorA_ncMO 142 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 314 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 247 bp overlap

TAF1 3 datasets

ChIP H1 ENCFF478SZO 479 bp overlap

ChIP H1 ENCFF478SZO 419 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 167 bp overlap

ChIP PRIMA2 GSE33850.TAL1.PRIMA2 127 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 185 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 224 bp overlap

TEAD1 1 dataset

ChIP pancreas_12D ERP008682.TEAD1.pancreas_12D 145 bp overlap

TEAD4 5 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 312 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP MCF-7_BLRP_WT_E2 GSE125594.TEAD4.MCF-7_BLRP_WT_E2 237 bp overlap

ChIP MCF-7_BLRP_WT_Veh GSE125594.TEAD4.MCF-7_BLRP_WT_Veh 219 bp overlap

ChIP SNU-216 GSE44416.TEAD4.SNU-216 247 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 417 bp overlap

TGIF2 1 dataset

ChIP WTC11 ENCFF649SHI 441 bp overlap

ChIP THP-1_1d_1-25-OH-2D3 GSE89431.VDR.THP-1_1d_1-25-OH-2D3 172 bp overlap

ChIP HEK293 ENCSR966PJJ.WT1.HEK293 219 bp overlap

ChIP Huh-7 GSE97411.YY1.Huh-7 250 bp overlap

ZBTB6 1 dataset

ChIP HEK293 GSE76494.ZBTB6.HEK293 152 bp overlap

ChIP HEK293 ENCFF033NQQ 130 bp overlap

ZNF143 1 dataset

ChIP WA01 ENCSR000EBW.ZNF143.WA01 113 bp overlap

ZNF257 1 dataset

ChIP HEK293T GSE78099.ZNF257.HEK293T 137 bp overlap

ZNF273 1 dataset

ChIP HEK293T GSE78099.ZNF273.HEK293T 245 bp overlap

ZNF281 2 datasets

ChIP WTC11 ENCFF551GAV 377 bp overlap

ChIP WTC11 ENCFF551GAV 323 bp overlap

ZNF341 3 datasets

ChIP HEK293 ENCFF944VMC 294 bp overlap

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 364 bp overlap

ChIP HEK293 GSE76494.ZNF341.HEK293 234 bp overlap

ZNF398 1 dataset

ChIP H9 GSE133630.ZNF398.H9 221 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 317 bp overlap

ZNF462 2 datasets

ChIP GM23338 ENCFF896CCA 251 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 168 bp overlap

ZNF467 1 dataset

ChIP HEK293 GSE76494.ZNF467.HEK293 211 bp overlap

ZNF770 2 datasets

ChIP HEK293 ENCSR242BGR.ZNF770.HEK293 250 bp overlap

ChIP HEK293 GSE76494.ZNF770.HEK293 175 bp overlap

ZSCAN22 1 dataset

ChIP HEK293 GSE76494.ZSCAN22.HEK293 202 bp overlap