Enables amino acid:proton symporter activity. Involved in L-glutamate transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC25A18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,264,343–17,265,119 | 298.8 kb | Distal (>10kb) Multiome | 164 | |
| chr22:17,266,034–17,267,197 | 296.8 kb | Distal (>10kb) Multiome | 366 | |
| chr22:17,272,506–17,273,119 | 290.7 kb | Distal (>10kb) Multiome | 82 | |
| chr22:17,366,817–17,367,342 | 196.4 kb | Distal (>10kb) Multiome | 186 | |
| chr22:17,368,390–17,370,790 | 194.2 kb | Distal (>10kb) Multiome | 494 | |
| chr22:17,379,144–17,379,660 | 184.0 kb | Distal (>10kb) Multiome | 126 | |
| chr22:17,628,467–17,629,189 | 65.4 kb | Distal (>10kb) Multiome | 714 | |
| chr22:17,638,195–17,639,235 | 75.3 kb | Distal (>10kb) Multiome | 934 | |
| chr22:17,773,581–17,774,636 | 210.6 kb | Distal (>10kb) Multiome | 486 |
Genomic view of the SLC25A18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.