This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF273. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF273 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF273, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:64,665,580–64,666,699 | 237.2 kb | Distal (>10kb) Multiome | 558 | |
| chr7:64,793,972–64,795,082 | 108.9 kb | Distal (>10kb) Multiome | 726 | |
| chr7:64,887,970–64,889,709 | 15.0 kb | Distal (>10kb) Multiome | 308 | |
| chr7:64,902,559–64,903,772 | 122 bp | At TSS Multiome | 497 | |
| chr7:65,006,175–65,006,968 | 103.4 kb | Distal (>10kb) Multiome | 666 | |
| chr7:65,037,736–65,039,147 | 134.9 kb | Distal (>10kb) Multiome | 335 | |
| chr7:65,080,759–65,081,624 | 178.0 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the ZNF273 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.