This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ADA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,084,375–17,085,889 | 114.7 kb | Distal (>10kb) Multiome | 653 | |
| chr22:17,089,112–17,089,816 | 110.2 kb | Distal (>10kb) Multiome | 16 | |
| chr22:17,119,575–17,121,998 | 78.1 kb | Distal (>10kb) Multiome | 547 | |
| chr22:17,158,472–17,160,056 | 40.4 kb | Distal (>10kb) Multiome | 673 | |
| chr22:17,171,206–17,172,533 | 27.9 kb | Distal (>10kb) Multiome | 796 | |
| chr22:17,198,160–17,199,752 | 110 bp | At TSS Multiome | 238 | |
| chr22:17,258,033–17,258,808 | 58.8 kb | Distal (>10kb) Multiome | 352 | |
| chr22:17,264,343–17,265,119 | 65.0 kb | Distal (>10kb) Multiome | 164 | |
| chr22:17,266,034–17,267,197 | 67.0 kb | Distal (>10kb) Multiome | 366 | |
| chr22:17,272,506–17,273,119 | 73.1 kb | Distal (>10kb) Multiome | 82 | |
| chr22:17,366,817–17,367,342 | 167.4 kb | Distal (>10kb) Multiome | 186 | |
| chr22:17,368,390–17,370,790 | 169.6 kb | Distal (>10kb) Multiome | 494 | |
| chr22:17,379,144–17,379,660 | 179.8 kb | Distal (>10kb) Multiome | 126 |
Genomic view of the ADA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.