Transcription factors with Perturb-seq knockdown data for ENSG00000290931. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290931 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290931, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,084,375–17,085,889 | 48.3 kb | Distal (>10kb) Multiome | 653 | |
| chr22:17,089,112–17,089,816 | 52.8 kb | Distal (>10kb) Multiome | 16 | |
| chr22:17,119,575–17,121,998 | 84.9 kb | Distal (>10kb) Multiome | 547 | |
| chr22:17,158,472–17,160,056 | 122.7 kb | Distal (>10kb) Multiome | 673 | |
| chr22:17,171,206–17,172,533 | 135.2 kb | Distal (>10kb) Multiome | 796 | |
| chr22:17,198,160–17,199,752 | 162.9 kb | Distal (>10kb) Multiome | 238 | |
| chr22:17,258,033–17,258,808 | 221.8 kb | Distal (>10kb) Multiome | 352 | |
| chr22:17,264,343–17,265,119 | 228.1 kb | Distal (>10kb) Multiome | 164 | |
| chr22:17,266,034–17,267,197 | 230.1 kb | Distal (>10kb) Multiome | 366 | |
| chr22:17,272,506–17,273,119 | 236.2 kb | Distal (>10kb) Multiome | 82 |
Genomic view of the ENSG00000290931 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.