chr12:125,104,917–125,105,989

chr12 : 125,104,917 – 125,105,989

1,072 bp 104 TFs 6 linked genes

This 1.1 kb open chromatin element is linked to 6 target genes and is bound by 104 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
AACS		4.0 kb	Proximal	Proximity
TMEM132B		80.7 kb	Distal	Multiome
BRI3BP		112.0 kb	Distal	Multiome
DHX37		116.6 kb	Distal	Multiome
UBC		191.1 kb	Distal	Multiome
SCARB1		241.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

104 transcription factors

ChIP MCF-7 GSE48930.AR.MCF-7 152 bp overlap

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 285 bp overlap

ChIP K562 ENCFF938UXQ 218 bp overlap

ChIP SK-MEL-28 GSE85352.ARNT.SK-MEL-28 514 bp overlap

ARNT::HIF1A 2 datasets

Motif DE_60h DE_60h-ARNTHIF1A_MA0259.2 5 bp overlap

Motif DE_72h DE_72h-ARNTHIF1A_MA0259.2 5 bp overlap

Atoh1 2 datasets

Motif DE_60h DE_60h-Atoh1_MA1467.3 7 bp overlap

Motif DE_72h DE_72h-Atoh1_MA1467.3 7 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BAP1.NCI-H1963_shNONT 468 bp overlap

BARX2 1 dataset

Motif DE_60h DE_60h-BARX2_MA1471.2 9 bp overlap

BHLHE40 2 datasets

ChIP K-562 ENCSR000EGV.BHLHE40.K-562 258 bp overlap

ChIP K562 ENCFF923NJI 311 bp overlap

ChIP K-562_DMSO GSE138084.BRD3.K-562_DMSO 202 bp overlap

BRD4 4 datasets

ChIP K-562_iBET-BD2-IFNG GSE138084.BRD4.K-562_iBET-BD2-IFNG 241 bp overlap

ChIP NCI-H1963_dBET6 GSE145028.BRD4.NCI-H1963_dBET6 783 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 648 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 698 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 316 bp overlap

ChIP K562 ENCFF963TXY 163 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 380 bp overlap

ChIP K562 ENCFF673OEZ 277 bp overlap

CEBPB 4 datasets

ChIP K-562 ENCSR000EHE.CEBPB.K-562 197 bp overlap

ChIP K-562 ENCSR000BRQ.CEBPB.K-562 175 bp overlap

ChIP K562 ENCFF189VBN 271 bp overlap

ChIP K562 ENCFF194QGF 321 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 168 bp overlap

ChIP K-562 ENCSR077DKV.CREM.K-562 109 bp overlap

CTBP1 2 datasets

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 397 bp overlap

ChIP K562 ENCFF403WPG 525 bp overlap

CTCF 6 datasets

ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 269 bp overlap

ChIP HAP1_clone21_CTCF-TSS-CRISPR_1 GSE152721.CTCF.HAP1_clone21_CTCF-TSS-CRISPR_1 239 bp overlap

ChIP HAP1_clone21_TSS-CRISPR GSE152721.CTCF.HAP1_clone21_TSS-CRISPR 176 bp overlap

ChIP anterior-temporal-cortex_fetal GSE116825.CTCF.anterior-temporal-cortex_fetal 154 bp overlap

ChIP neural ENCSR822CEA.CTCF.neural 293 bp overlap

ChIP neural cell ENCFF335ADI 505 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 251 bp overlap

DNMT3B 2 datasets

ChIP HUES-8 GSE99346.DNMT3B.HUES-8 288 bp overlap

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 313 bp overlap

DPF2 2 datasets

ChIP K-562 ENCSR219BXP.DPF2.K-562 398 bp overlap

ChIP K562 ENCFF775HUO 256 bp overlap

DUX4 2 datasets

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 177 bp overlap

ChIP hESC GSE26097.EOMES.hESC 365 bp overlap

EPAS1 2 datasets

Motif DE_60h DE_60h-EPAS1_MA2325.1 9 bp overlap

Motif DE_72h DE_72h-EPAS1_MA2325.1 9 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 407 bp overlap

ChIP DE DE-FOXA2-1 458 bp overlap

ChIP DE DE-FOXA2-2 430 bp overlap

ChIP DE DE-FOXA2-2 460 bp overlap

GATA1 7 datasets

ChIP CD34_Day7_30min GSE104676.GATA1.CD34_Day7_30min 131 bp overlap

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 55 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 318 bp overlap

ChIP K-562 ENCSR000EWM.GATA1.K-562 189 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 263 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 239 bp overlap

ChIP erythroblast ENCSR000EXP.GATA1.erythroblast 448 bp overlap

GATA2 3 datasets

ChIP K-562 ENCSR000BKM.GATA2.K-562 123 bp overlap

ChIP K-562 ENCSR000EWG.GATA2.K-562 130 bp overlap

ChIP K562 ENCFF544PCK 251 bp overlap

GATA4 9 datasets

ChIP DE DE-GATA4-1 983 bp overlap

ChIP DE DE-GATA4-2 982 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 280 bp overlap

ChIP foregut GSE117136.GATA4.foregut 360 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 457 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 362 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 362 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 992 bp overlap

ChIP DE DE-GATA6-2 977 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 1030 bp overlap

ChIP PATU8988 GSE47535.GATA6.PATU8988 401 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 236 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 978 bp overlap

ChIP foregut GSE117136.GATA6.foregut 431 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 316 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 442 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 299 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 342 bp overlap

HAND2 2 datasets

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

Motif DE_72h DE_72h-HAND2_MA1638.2 6 bp overlap

HDAC1 1 dataset

ChIP K-562 ENCSR387UWP.HDAC1.K-562 215 bp overlap

HDAC2 3 datasets

ChIP K-562 ENCSR075HTM.HDAC2.K-562 338 bp overlap

ChIP K-562 ENCSR893WSB.HDAC2.K-562 249 bp overlap

ChIP K562 ENCFF744ALD 421 bp overlap

HIF1A 2 datasets

Motif DE_60h DE_60h-HIF1A_MA1106.2 6 bp overlap

Motif DE_72h DE_72h-HIF1A_MA1106.2 6 bp overlap

HNRNPLL 1 dataset

ChIP K-562 ENCSR112RNT.HNRNPLL.K-562 217 bp overlap

HOXA4 1 dataset

Motif DE_60h DE_60h-HOXA4_MA1496.2 7 bp overlap

HOXB4 1 dataset

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

HOXC4 1 dataset

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

HOXD4 1 dataset

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

IKZF1 1 dataset

ChIP pre-B-cell GSE107886.IKZF1.pre-B-cell 100 bp overlap

JUND 2 datasets

ChIP K-562 ENCSR000EGN.JUND.K-562 186 bp overlap

ChIP K562 ENCFF830LVJ 281 bp overlap

KDM1A 1 dataset

ChIP K-562 GSE117944.KDM1A.K-562 208 bp overlap

KLF1 4 datasets

ChIP HEK293 ENCFF159QSW 169 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 332 bp overlap

ChIP HEK293 GSE76494.KLF1.HEK293 163 bp overlap

ChIP erythroid_R3R4 GSE43625.KLF1.erythroid_R3R4 65 bp overlap

KLF4 2 datasets

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 128 bp overlap

ChIP HAP1 GSE130417.KLF4.HAP1 290 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 150 bp overlap

ChIP K562 ENCFF524IJO 397 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 287 bp overlap

ChIP HEK293 GSE76494.MAZ.HEK293 223 bp overlap

ChIP K-562 ENCSR000EFX.MAZ.K-562 180 bp overlap

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 199 bp overlap

MEIS2 2 datasets

ChIP K-562 ENCSR851BNE.MEIS2.K-562 292 bp overlap

ChIP K562 ENCFF320GSD 381 bp overlap

ChIP K-562 ENCSR000FAG.MYC.K-562 110 bp overlap

NCOR1 1 dataset

ChIP K-562 ENCSR798ILC.NCOR1.K-562 208 bp overlap

NEUROD1 2 datasets

Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_72h DE_72h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 2 datasets

Motif DE_60h DE_60h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_72h DE_72h-NEUROG2_MA1642.2 7 bp overlap

ChIP K-562 ENCSR000FCC.NFE2.K-562 115 bp overlap

Neurod2 2 datasets

Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap

Motif DE_72h DE_72h-Neurod2_MA0668.3 8 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 348 bp overlap

PKNOX1 2 datasets

ChIP K-562 ENCSR115SMW.PKNOX1.K-562 381 bp overlap

ChIP K562 ENCFF236IUS 457 bp overlap

POLR2A 2 datasets

ChIP neural cell ENCFF604SPB 385 bp overlap

ChIP neural cell ENCFF604SPB 385 bp overlap

POU6F1 1 dataset

Motif DE_60h DE_60h-POU6F1_MA1549.2 7 bp overlap

Ptf1A 2 datasets

Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1618.2 9 bp overlap

RARA 2 datasets

ChIP hiPSC_D3 GSE109172.RARA.hiPSC_D3 270 bp overlap

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 446 bp overlap

RCOR1 1 dataset

ChIP K562 ENCFF216EEJ 297 bp overlap

Motif DE_60h DE_60h-REL_MA0101.1 10 bp overlap

Motif DE_72h DE_72h-REL_MA0101.1 10 bp overlap

ChIP neural ENCSR000BTV.REST.neural 365 bp overlap

RUNX1 1 dataset

ChIP Jurkat GSE85524.RUNX1.Jurkat 201 bp overlap

SCRT1 2 datasets

Motif DE_60h DE_60h-SCRT1_MA0743.3 10 bp overlap

Motif DE_72h DE_72h-SCRT1_MA0743.3 10 bp overlap

SETDB1 1 dataset

ChIP K-562 ENCSR000EWI.SETDB1.K-562 194 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 176 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 941 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 976 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 925 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 227 bp overlap

SMARCA4 3 datasets

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 238 bp overlap

ChIP K-562 ENCSR587OQL.SMARCA4.K-562 326 bp overlap

ChIP NSC GSE125033.SMARCA4.NSC 914 bp overlap

SOX10 2 datasets

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 414 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 999 bp overlap

ChIP HNSC GSE69479.SOX2.HNSC 461 bp overlap

SOX4 2 datasets

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap

ChIP HEK293 ENCSR468IJT.SP7.HEK293 264 bp overlap

Motif DE_60h DE_60h-SRF_MA0083.3 16 bp overlap

Motif DE_72h DE_72h-SRF_MA0083.3 16 bp overlap

STAT1 2 datasets

Motif DE_60h DE_60h-STAT1_MA0137.4 9 bp overlap

Motif DE_72h DE_72h-STAT1_MA0137.4 9 bp overlap

STAT3 2 datasets

Motif DE_60h DE_60h-STAT3_MA0144.3 9 bp overlap

Motif DE_72h DE_72h-STAT3_MA0144.3 9 bp overlap

Sox5 2 datasets

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Stat2 2 datasets

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

Stat4 2 datasets

Motif DE_60h DE_60h-Stat4_MA0518.2 10 bp overlap

Motif DE_72h DE_72h-Stat4_MA0518.2 10 bp overlap

Stat5a 2 datasets

Motif DE_60h DE_60h-Stat5a_MA1624.2 9 bp overlap

Motif DE_72h DE_72h-Stat5a_MA1624.2 9 bp overlap

Stat5a::Stat5b 2 datasets

Motif DE_60h DE_60h-Stat5aStat5b_MA0519.2 9 bp overlap

Motif DE_72h DE_72h-Stat5aStat5b_MA0519.2 9 bp overlap

Stat5b 2 datasets

Motif DE_60h DE_60h-Stat5b_MA1625.2 9 bp overlap

Motif DE_72h DE_72h-Stat5b_MA1625.2 9 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 242 bp overlap

TAL1 13 datasets

ChIP CD34 GSE52924.TAL1.CD34 161 bp overlap

ChIP K-562 ENCSR106FRG.TAL1.K-562 337 bp overlap

ChIP K-562 GSE107726.TAL1.K-562 242 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 198 bp overlap

ChIP K-562_MYO1D-Non-hub_KO GSE107726.TAL1.K-562_MYO1D-Non-hub_KO 187 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 274 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 282 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 256 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 262 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 211 bp overlap

ChIP K562 ENCFF620GMX 167 bp overlap

ChIP K562 ENCFF661CCK 277 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 117 bp overlap

TCF12 2 datasets

ChIP K-562 ENCSR744WOO.TCF12.K-562 280 bp overlap

ChIP K562 ENCFF931DJY 174 bp overlap

TCF3 2 datasets

ChIP K-562 ENCSR970OJY.TCF3.K-562 295 bp overlap

ChIP K562 ENCFF319QZT 381 bp overlap

TEAD4 2 datasets

ChIP K562 ENCFF673NIK 365 bp overlap

ChIP K562 ENCFF673NIK 365 bp overlap

ChIP IMR-90_SENES_SHLUC GSE42728.TP53.IMR-90_SENES_SHLUC 128 bp overlap

TRIM24 1 dataset

ChIP K-562 ENCSR957LDM.TRIM24.K-562 201 bp overlap

ChIP K-562 ENCSR000BMH.YY1.K-562 106 bp overlap

ZBTB7A 2 datasets

ChIP K-562 GSE103445.ZBTB7A.K-562 206 bp overlap

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 147 bp overlap

ZEB2 4 datasets

ChIP K-562 ENCSR322CFO.ZEB2.K-562 252 bp overlap

ChIP K-562 ENCSR004GKA.ZEB2.K-562 248 bp overlap

ChIP K562 ENCFF795CMH 477 bp overlap

ChIP K562 ENCFF975RXS 461 bp overlap

ChIP HEK293 ENCFF033NQQ 356 bp overlap

ZKSCAN1 1 dataset

ChIP K-562 ENCSR882ERE.ZKSCAN1.K-562 143 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 417 bp overlap

ZNF35 1 dataset

ChIP HEK293 GSE76494.ZNF35.HEK293 174 bp overlap

ZNF554 1 dataset

ChIP HEK293 GSE76494.ZNF554.HEK293 139 bp overlap

ZNF667 2 datasets

Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap

ZNF736 1 dataset

ChIP HEK293T GSE78099.ZNF736.HEK293T 278 bp overlap

ZNF770 1 dataset

ChIP HEK293 GSE76494.ZNF770.HEK293 162 bp overlap

Znf423 2 datasets

Motif DE_60h DE_60h-Znf423_MA0116.1 15 bp overlap

Motif DE_72h DE_72h-Znf423_MA0116.1 15 bp overlap