Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRI3BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRI3BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRI3BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:124,734,326–124,734,809 | 259.1 kb | Distal (>10kb) Multiome | 298 | |
| chr12:124,807,344–124,807,806 | 186.0 kb | Distal (>10kb) Multiome | 114 | |
| chr12:124,863,018–124,864,505 | 129.7 kb | Distal (>10kb) Multiome | 853 | |
| chr12:124,988,779–124,989,361 | 4.6 kb | Proximal (<10kb) Multiome | 612 | |
| chr12:124,992,895–124,993,156 | 547 bp | At TSS | 526 | |
| chr12:124,993,323–124,994,466 | 80 bp | At TSS Multiome | 599 | |
| chr12:125,049,168–125,050,306 | 56.0 kb | Distal (>10kb) Multiome | 508 | |
| chr12:125,064,544–125,066,015 | 71.6 kb | Distal (>10kb) Multiome HiCAR | 709 | |
| chr12:125,098,677–125,099,386 | 105.3 kb | Distal (>10kb) Multiome | 99 | |
| chr12:125,100,438–125,101,144 | 107.1 kb | Distal (>10kb) Multiome | 195 | |
| chr12:125,104,917–125,105,989 | 112.0 kb | Distal (>10kb) Multiome | 104 | |
| chr12:125,183,066–125,184,076 | 189.7 kb | Distal (>10kb) Multiome | 415 | |
| chr12:125,184,417–125,187,758 | 192.6 kb | Distal (>10kb) Multiome | 530 | |
| chr12:125,188,188–125,188,856 | 194.9 kb | Distal (>10kb) Multiome | 101 | |
| chr12:125,220,221–125,220,987 | 226.8 kb | Distal (>10kb) Multiome | 201 | |
| chr12:125,236,876–125,237,541 | 243.5 kb | Distal (>10kb) Multiome | 187 | |
| chr12:125,280,415–125,281,352 | 287.1 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the BRI3BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.