SCARB1
scavenger receptor class B member 1 | CLA-1, CLA1, SR-BI, SRB1, CD36L1

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]

Member of: DE-2 Developmental clusters: GC3
Biological processes 74 terms
1-phosphatidylinositol binding (GO:0005545)adhesion of symbiont to host (GO:0044406)amyloid-beta binding (GO:0001540)apolipoprotein A-I binding (GO:0034186)apolipoprotein binding (GO:0034185)apolipoprotein binding (GO:0034185)caveola (GO:0005901)caveola (GO:0005901)caveola (GO:0005901)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cholesterol homeostasis (GO:0042632)cholesterol homeostasis (GO:0042632)cholesterol import (GO:0070508)cholesterol import (GO:0070508)cholesterol import (GO:0070508)cholesterol import (GO:0070508)cytoplasm (GO:0005737)detection of lipopolysaccharide (GO:0032497)endocytic vesicle membrane (GO:0030666)extracellular exosome (GO:0070062)high density lipoprotein particle mediated signaling (GO:0055097)high-density lipoprotein particle binding (GO:0008035)high-density lipoprotein particle binding (GO:0008035)high-density lipoprotein particle clearance (GO:0034384)high-density lipoprotein particle receptor activity (GO:0070506)high-density lipoprotein particle receptor activity (GO:0070506)high-density lipoprotein particle remodeling (GO:0034375)high-density lipoprotein particle remodeling (GO:0034375)lipid binding (GO:0008289)lipid transport (GO:0006869)lipopolysaccharide binding (GO:0001530)lipopolysaccharide immune receptor activity (GO:0001875)lipopolysaccharide transport (GO:0015920)lipopolysaccharide-mediated signaling pathway (GO:0031663)low-density lipoprotein particle binding (GO:0030169)low-density lipoprotein particle binding (GO:0030169)low-density lipoprotein particle clearance (GO:0034383)low-density lipoprotein particle clearance (GO:0034383)lysosomal membrane (GO:0005765)membrane (GO:0016020)phosphatidylserine binding (GO:0001786)phospholipid transport (GO:0015914)phospholipid transport (GO:0015914)plasma lipoprotein particle clearance (GO:0034381)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cholesterol storage (GO:0010886)positive regulation of endothelial cell migration (GO:0010595)positive regulation of nitric oxide-cGMP mediated signal transduction (GO:0141150)positive regulation of sphingolipid mediated signaling pathway (GO:1902070)positive regulation of triglyceride biosynthetic process (GO:0010867)positive regulation of triglyceride biosynthetic process (GO:0010867)protein binding (GO:0005515)recognition of apoptotic cell (GO:0043654)recognition of apoptotic cell (GO:0043654)regulation of phagocytosis (GO:0050764)regulation of phosphatidylcholine catabolic process (GO:0010899)regulation of phosphatidylcholine catabolic process (GO:0010899)reverse cholesterol transport (GO:0043691)reverse cholesterol transport (GO:0043691)scavenger receptor activity (GO:0005044)scavenger receptor activity (GO:0005044)triglyceride homeostasis (GO:0070328)triglyceride homeostasis (GO:0070328)vasodilation (GO:0042311)vitamin transmembrane transport (GO:0035461)wound healing (GO:0042060)
Expression (TPM)
SCARB1 — as a Regulated Gene

TFs regulating SCARB1 0 TFs

Transcription factors with Perturb-seq knockdown data for SCARB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCARB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SCARB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCARB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr12:124,566,229–124,568,213 297.2 kb Distal (>10kb) Multiome 705
chr12:124,605,711–124,606,156 257.9 kb Distal (>10kb) Multiome 139
chr12:124,734,326–124,734,809 129.2 kb Distal (>10kb) Multiome 298
chr12:124,807,344–124,807,806 56.1 kb Distal (>10kb) Multiome 114
chr12:124,863,018–124,864,505 172 bp At TSS Multiome 853
chr12:124,869,170–124,869,508 5.2 kb Proximal (<10kb) 259
chr12:124,988,779–124,989,361 125.4 kb Distal (>10kb) Multiome 612
chr12:124,993,323–124,994,466 130.0 kb Distal (>10kb) Multiome 599
chr12:125,049,168–125,050,306 185.9 kb Distal (>10kb) Multiome 508
chr12:125,064,544–125,066,015 201.5 kb Distal (>10kb) Multiome 709
chr12:125,098,677–125,099,386 235.3 kb Distal (>10kb) Multiome 99
chr12:125,100,438–125,101,144 237.1 kb Distal (>10kb) Multiome 195
chr12:125,104,917–125,105,989 241.9 kb Distal (>10kb) Multiome 104

Genome Browser

Genomic view of the SCARB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr12:124,556,229 – 125,115,989
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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