Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM132B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM132B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM132B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:124,988,779–124,989,361 | 197.2 kb | Distal (>10kb) Multiome | 612 | |
| chr12:124,993,323–124,994,466 | 192.6 kb | Distal (>10kb) Multiome | 599 | |
| chr12:125,049,168–125,050,306 | 136.7 kb | Distal (>10kb) Multiome | 508 | |
| chr12:125,064,544–125,066,015 | 121.1 kb | Distal (>10kb) Multiome | 709 | |
| chr12:125,098,677–125,099,386 | 87.3 kb | Distal (>10kb) Multiome | 99 | |
| chr12:125,100,438–125,101,144 | 85.5 kb | Distal (>10kb) Multiome | 195 | |
| chr12:125,104,917–125,105,989 | 80.7 kb | Distal (>10kb) Multiome | 104 | |
| chr12:125,183,066–125,184,076 | 3.0 kb | Proximal (<10kb) Multiome | 415 | |
| chr12:125,184,417–125,187,758 | 46 bp | At TSS Multiome | 530 | |
| chr12:125,188,188–125,188,856 | 2.2 kb | Proximal (<10kb) Multiome | 101 | |
| chr12:125,220,221–125,220,987 | 34.2 kb | Distal (>10kb) Multiome | 201 | |
| chr12:125,236,876–125,237,541 | 50.8 kb | Distal (>10kb) Multiome | 187 | |
| chr12:125,280,415–125,281,352 | 94.4 kb | Distal (>10kb) Multiome | 227 | |
| chr12:125,330,758–125,331,650 | 144.8 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr12:125,683,679–125,684,134 | 497.6 kb | Distal (>10kb) Multiome HiCAR | 210 | |
| chr12:126,107,781–126,108,676 | 922.0 kb | Distal (>10kb) Multiome HiCAR | 114 |
Genomic view of the TMEM132B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.