This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for UBC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:124,734,326–124,734,809 | 180.1 kb | Distal (>10kb) Multiome | 298 | |
| chr12:124,807,344–124,807,806 | 107.0 kb | Distal (>10kb) Multiome | 114 | |
| chr12:124,863,018–124,864,505 | 50.7 kb | Distal (>10kb) Multiome | 853 | |
| chr12:124,988,779–124,989,361 | 74.5 kb | Distal (>10kb) Multiome | 612 | |
| chr12:124,993,323–124,994,466 | 79.1 kb | Distal (>10kb) Multiome | 599 | |
| chr12:125,049,168–125,050,306 | 135.1 kb | Distal (>10kb) Multiome | 508 | |
| chr12:125,064,544–125,066,015 | 150.7 kb | Distal (>10kb) Multiome | 709 | |
| chr12:125,098,677–125,099,386 | 184.4 kb | Distal (>10kb) Multiome | 99 | |
| chr12:125,100,438–125,101,144 | 186.2 kb | Distal (>10kb) Multiome | 195 | |
| chr12:125,104,917–125,105,989 | 191.1 kb | Distal (>10kb) Multiome | 104 | |
| chr12:125,183,066–125,184,076 | 268.7 kb | Distal (>10kb) Multiome | 415 | |
| chr12:125,184,417–125,187,758 | 271.7 kb | Distal (>10kb) Multiome | 530 | |
| chr12:125,188,188–125,188,856 | 273.9 kb | Distal (>10kb) Multiome | 101 |
Genomic view of the UBC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.