chr5:141,858,059–141,858,606

chr5 : 141,858,059 – 141,858,606

547 bp 80 TFs 11 linked genes

This 547 bp open chromatin element is linked to 11 target genes and is bound by 80 transcription factors.

Linked Genes

11 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PCDH1		20.1 kb	Distal	Multiome
ENSG00000287726		25.2 kb	Distal	Multiome
DELE1		65.6 kb	Distal	Multiome
RNF14		110.8 kb	Distal	Multiome
GNPDA1		154.7 kb	Distal	Multiome
ARAP3		176.1 kb	Distal	Multiome
FCHSD1		206.9 kb	Distal	Multiome
RELL2		221.4 kb	Distal	Multiome
HDAC3		221.5 kb	Distal	Multiome
DIAPH1		239.4 kb	Distal	Multiome
NDFIP1		250.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

80 transcription factors

ChIP LNCaP_D226N_shFOXA1_Ethanol GSE128883.AR.LNCaP_D226N_shFOXA1_Ethanol 171 bp overlap

ASH2L 3 datasets

ChIP H1 ENCFF399KAM 547 bp overlap

ChIP H1 ENCFF399KAM 474 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 547 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 188 bp overlap

BACH1 1 dataset

ChIP WA01 ENCSR000EBQ.BACH1.WA01 246 bp overlap

BRD4 3 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 298 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 396 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 547 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 183 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 124 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF274GAT 59 bp overlap

ELF3 2 datasets

ChIP PDAC GSE64557.ELF3.PDAC 489 bp overlap

ChIP PDAC_SHCTR GSE64557.ELF3.PDAC_SHCTR 469 bp overlap

EP300 2 datasets

ChIP WA01 ENCSR000BKK.EP300.WA01 210 bp overlap

ChIP WA01 ENCSR000AUQ.EP300.WA01 126 bp overlap

ChIP primary-endometrium-cancer_E1_DSG GSE114737.ESR1.primary-endometrium-cancer_E1_DSG 425 bp overlap

EWSR1-FLI1 3 datasets

Motif DE_36h DE_36h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_48h DE_48h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_72h DE_72h-EWSR1-FLI1_MA0149.1 18 bp overlap

EZH2 3 datasets

ChIP DND41 ENCSR000ASW.EZH2.DND41 249 bp overlap

ChIP RL_CPI169-10d GSE134136.EZH2.RL_CPI169-10d 83 bp overlap

ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 254 bp overlap

FIGLA 2 datasets

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FOXK1 1 dataset

ChIP WTC11 ENCFF875IGU 391 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-2 297 bp overlap

ChIP foregut GSE117136.GATA4.foregut 388 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 304 bp overlap

ChIP DE DE-GATA6-2 325 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 449 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 386 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 496 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 376 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 430 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 514 bp overlap

ChIP foregut GSE117136.GATA6.foregut 420 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 362 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 246 bp overlap

HDAC2 5 datasets

ChIP H1 ENCFF353UJQ 468 bp overlap

ChIP H1 ENCFF353UJQ 514 bp overlap

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 340 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 164 bp overlap

HNF4A 1 dataset

ChIP KATO-III GSE114018.HNF4A.KATO-III 271 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 230 bp overlap

ChIP WA01 ENCSR000BKP.JUND.WA01 188 bp overlap

KLF5 4 datasets

Motif DE_36h DE_36h-KLF5_MA0599.1 10 bp overlap

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

Motif DE_72h DE_72h-KLF5_MA0599.1 10 bp overlap

ChIP HEK293_E419Q GSE88976.KLF5.HEK293_E419Q 365 bp overlap

ChIP WA01 ENCSR000EUP.MAX.WA01 138 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 262 bp overlap

ChIP HEK293 GSE76494.MAZ.HEK293 198 bp overlap

ChIP HCT-116 GSE121798.MED1.HCT-116 93 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 434 bp overlap

ChIP hESC GSE18292.NANOG.hESC 147 bp overlap

NFATC3 3 datasets

Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NFATC4 3 datasets

Motif DE_36h DE_36h-NFATC4_MA1525.3 9 bp overlap

Motif DE_48h DE_48h-NFATC4_MA1525.3 9 bp overlap

Motif DE_72h DE_72h-NFATC4_MA1525.3 9 bp overlap

NFKB1 1 dataset

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 160 bp overlap

Nfat5 3 datasets

Motif DE_36h DE_36h-Nfat5_MA0606.3 8 bp overlap

Motif DE_48h DE_48h-Nfat5_MA0606.3 8 bp overlap

Motif DE_72h DE_72h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 3 datasets

Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 3 datasets

Motif DE_36h DE_36h-Nfatc2_MA0152.3 8 bp overlap

Motif DE_48h DE_48h-Nfatc2_MA0152.3 8 bp overlap

Motif DE_72h DE_72h-Nfatc2_MA0152.3 8 bp overlap

POLR2A 3 datasets

ChIP body of pancreas ENCFF501FEC 514 bp overlap

ChIP body of pancreas ENCFF675RCN 516 bp overlap

ChIP body of pancreas ENCFF675RCN 316 bp overlap

POU2F1 1 dataset

ChIP T-47D GSE148277.POU2F1.T-47D 183 bp overlap

POU5F1 1 dataset

ChIP HUES-8 GSE109524.POU5F1.HUES-8 418 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 325 bp overlap

PRDM14 1 dataset

ChIP NCCIT GSE71675.PRDM14.NCCIT 276 bp overlap

PRDM9 3 datasets

Motif DE_36h DE_36h-PRDM9_MA1723.2 20 bp overlap

Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 352 bp overlap

RELA 6 datasets

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 226 bp overlap

ChIP HUVEC-C_TNF-30min GSE121890.RELA.HUVEC-C_TNF-30min 121 bp overlap

ChIP HUVEC-C_TNF_30M GSE34500.RELA.HUVEC-C_TNF_30M 121 bp overlap

ChIP LNCaP_SIFOXA1_TNFA GSE83860.RELA.LNCaP_SIFOXA1_TNFA 317 bp overlap

ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 340 bp overlap

ChIP aortic-endothelial-cell_IL1B_D7 GSE139377.RELA.aortic-endothelial-cell_IL1B_D7 241 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000EBO.SIN3A.WA01 259 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 271 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 451 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 270 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 199 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 339 bp overlap

SMARCB1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 197 bp overlap

SMARCC1 2 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 354 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 223 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 547 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 220 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 450 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 305 bp overlap

ChIP HEK293 GSE76494.SP1.HEK293 204 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 314 bp overlap

ChIP WTC11 ENCFF688PEU 441 bp overlap

Motif DE_36h DE_36h-SP4_MA0685.2 9 bp overlap

Motif DE_48h DE_48h-SP4_MA0685.2 9 bp overlap

Motif DE_72h DE_72h-SP4_MA0685.2 9 bp overlap

ChIP H1 ENCFF473YOB 498 bp overlap

ChIP H1 ENCFF473YOB 418 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 249 bp overlap

Motif DE_36h DE_36h-SP5_MA1965.2 6 bp overlap

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

STAT3 8 datasets

ChIP HCC1187 GSE152203.STAT3.HCC1187 369 bp overlap

ChIP HCC70 GSE152203.STAT3.HCC70 165 bp overlap

ChIP HCC70_EtOH GSE85579.STAT3.HCC70_EtOH 381 bp overlap

ChIP T-47D_JC4753 GSE126004.STAT3.T-47D_JC4753 334 bp overlap

ChIP T-47D_JC4757 GSE126004.STAT3.T-47D_JC4757 259 bp overlap

ChIP T-47D_JC5054 GSE126004.STAT3.T-47D_JC5054 239 bp overlap

ChIP T-47D_JC5056 GSE126004.STAT3.T-47D_JC5056 420 bp overlap

ChIP T-47D_JC5062 GSE126004.STAT3.T-47D_JC5062 228 bp overlap

SUZ12 2 datasets

ChIP CRL-7250_shSS18 GSE108025.SUZ12.CRL-7250_shSS18 478 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 209 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 251 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 115 bp overlap

TCF12 2 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 132 bp overlap

ChIP NPC GSE154479.TCF3.NPC 275 bp overlap

TCF4 2 datasets

Motif DE_48h DE_48h-TCF4_MA0830.3 8 bp overlap

Motif DE_72h DE_72h-TCF4_MA0830.3 8 bp overlap

THAP1 3 datasets

Motif DE_36h DE_36h-THAP1_MA0597.3 8 bp overlap

Motif DE_48h DE_48h-THAP1_MA0597.3 8 bp overlap

Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap

THRA 2 datasets

Motif DE_48h DE_48h-THRA_MA1969.2 18 bp overlap

Motif DE_72h DE_72h-THRA_MA1969.2 18 bp overlap

THRB 2 datasets

Motif DE_48h DE_48h-THRB_MA1576.2 18 bp overlap

Motif DE_72h DE_72h-THRB_MA1576.2 18 bp overlap

TWIST1 2 datasets

ChIP BE2C GSE80151.TWIST1.BE2C 154 bp overlap

ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 154 bp overlap

ChIP kidney-cortex GSE129585.VDR.kidney-cortex 319 bp overlap

ChIP HEK293 ENCFF906HIR 186 bp overlap

ChIP HEK293 ENCSR966PJJ.WT1.HEK293 358 bp overlap

ChIP H1 ENCFF524BTL 337 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 261 bp overlap

ZBTB26 2 datasets

Motif DE_48h DE_48h-ZBTB26_MA1579.2 8 bp overlap

Motif DE_72h DE_72h-ZBTB26_MA1579.2 8 bp overlap

ZEB1 2 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ZFP14 3 datasets

Motif DE_36h DE_36h-ZFP14_MA1972.1 15 bp overlap

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

Motif DE_72h DE_72h-ZFP14_MA1972.1 15 bp overlap

ChIP HEK293 ENCFF033NQQ 120 bp overlap

ZNF257 1 dataset

ChIP HEK293T GSE78099.ZNF257.HEK293T 137 bp overlap

ZNF263 4 datasets

Motif DE_36h DE_36h-ZNF263_MA0528.3 7 bp overlap

Motif DE_48h DE_48h-ZNF263_MA0528.3 7 bp overlap

Motif DE_72h DE_72h-ZNF263_MA0528.3 7 bp overlap

ChIP WTC11 ENCFF893RTM 437 bp overlap

ZNF331 2 datasets

ChIP GM23338 ENCFF410NSZ 225 bp overlap

ChIP GM23338 ENCSR918LRB.ZNF331.GM23338 305 bp overlap

ZNF384 3 datasets

Motif DE_36h DE_36h-ZNF384_MA1125.2 8 bp overlap

Motif DE_48h DE_48h-ZNF384_MA1125.2 8 bp overlap

Motif DE_72h DE_72h-ZNF384_MA1125.2 8 bp overlap

ZNF440 1 dataset

ChIP HEK293T GSE78099.ZNF440.HEK293T 245 bp overlap

ZNF532 1 dataset

ChIP WTC11 ENCFF373VBX 225 bp overlap

ZNF701 2 datasets

Motif DE_48h DE_48h-ZNF701_MA1987.2 17 bp overlap

Motif DE_72h DE_72h-ZNF701_MA1987.2 17 bp overlap

ZNF768 2 datasets

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap

Motif DE_36h DE_36h-Zfx_MA0146.3 10 bp overlap

Motif DE_48h DE_48h-Zfx_MA0146.3 10 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap