GNPDA1

glucosamine-6-phosphate deaminase 1 | GNPDA, GPI, HLN, KIAA0060, GNPI

Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

Member of: DE-1

Biological processes 23 terms

N-acetylglucosamine catabolic process (GO:0006046)N-acetylglucosamine metabolic process (GO:0006044)N-acetylneuraminate catabolic process (GO:0019262)UDP-N-acetylglucosamine biosynthetic process (GO:0006048)UDP-N-acetylglucosamine biosynthetic process (GO:0006048)carbohydrate metabolic process (GO:0005975)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular exosome (GO:0070062)generation of precursor metabolites and energy (GO:0006091)glucosamine catabolic process (GO:0006043)glucosamine catabolic process (GO:0006043)glucosamine catabolic process (GO:0006043)glucosamine-6-phosphate deaminase activity (GO:0004342)glucosamine-6-phosphate deaminase activity (GO:0004342)glucosamine-6-phosphate deaminase activity (GO:0004342)glucosamine-6-phosphate deaminase activity (GO:0004342)glucosamine-6-phosphate deaminase activity (GO:0004342)identical protein binding (GO:0042802)protein binding (GO:0005515)single fertilization (GO:0007338)

Expression (TPM)

TFs regulating GNPDA1 0 TFs

Transcription factors with Perturb-seq knockdown data for GNPDA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNPDA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GNPDA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNPDA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:141,795,082–141,795,688	217.7 kb	Distal (>10kb) Multiome	25
chr5:141,811,578–141,812,181	201.2 kb	Distal (>10kb) Multiome	243
chr5:141,816,277–141,817,287	196.2 kb	Distal (>10kb) Multiome	210
chr5:141,838,853–141,839,539	173.8 kb	Distal (>10kb) Multiome	185
chr5:141,845,184–141,846,305	167.3 kb	Distal (>10kb) Multiome	188
chr5:141,848,609–141,851,214	163.7 kb	Distal (>10kb) Multiome	892
chr5:141,858,059–141,858,606	154.7 kb	Distal (>10kb) Multiome	80
chr5:141,875,925–141,877,406	136.8 kb	Distal (>10kb) Multiome	506
chr5:141,877,575–141,879,487	134.6 kb	Distal (>10kb) Multiome	693
chr5:141,923,268–141,924,400	89.1 kb	Distal (>10kb) Multiome	922
chr5:141,968,679–141,969,625	43.9 kb	Distal (>10kb) Multiome	966
chr5:142,012,158–142,013,413	14 bp	At TSS Multiome	665
chr5:142,083,687–142,084,682	71.1 kb	Distal (>10kb) Multiome	113
chr5:142,108,404–142,109,356	95.8 kb	Distal (>10kb) Multiome	759
chr5:142,169,261–142,169,978	156.5 kb	Distal (>10kb) Multiome	405
chr5:142,175,265–142,176,514	162.8 kb	Distal (>10kb) Multiome	230
chr5:142,279,944–142,281,216	267.3 kb	Distal (>10kb) Multiome	416
chr5:142,290,346–142,291,338	277.8 kb	Distal (>10kb) Multiome	377
chr5:142,295,103–142,296,598	282.5 kb	Distal (>10kb) Multiome	308

Genome Browser

Genomic view of the GNPDA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.