Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Cluster | Dir | NES | padj | Bind | OR | padj (bind) |
|---|
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by ZNF532 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to ZNF532 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where ZNF532 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for ZNF532. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF532 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF532, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:58,628,791–58,629,668 | 233.7 kb | Distal (>10kb) Multiome | 156 | |
| chr18:58,670,687–58,672,355 | 191.5 kb | Distal (>10kb) Multiome | 783 | |
| chr18:58,694,693–58,695,388 | 167.9 kb | Distal (>10kb) Multiome | 196 | |
| chr18:58,768,204–58,768,929 | 94.4 kb | Distal (>10kb) Multiome | 427 | |
| chr18:58,808,329–58,808,800 | 54.4 kb | Distal (>10kb) Multiome HiCAR | 44 | |
| chr18:58,829,548–58,830,499 | 33.0 kb | Distal (>10kb) Multiome | 168 | |
| chr18:58,846,800–58,849,106 | 15.1 kb | Distal (>10kb) Multiome | 416 | |
| chr18:58,863,566–58,864,932 | 1.4 kb | Proximal (<10kb) Multiome | 286 | |
| chr18:58,867,169–58,867,750 | 4.5 kb | Proximal (<10kb) Multiome | 136 | |
| chr18:58,872,378–58,872,683 | 9.4 kb | Proximal (<10kb) | 20 | |
| chr18:59,001,173–59,002,098 | 138.5 kb | Distal (>10kb) Multiome | 76 | |
| chr18:59,139,305–59,140,740 | 276.8 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the ZNF532 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.