NDFIP1

Nedd4 family interacting protein 1 | MGC10924, N4WBP5

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.3

Biological processes 19 terms

Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)cytoplasm (GO:0005737)dendrite (GO:0030425)endoplasmic reticulum (GO:0005783)endosome membrane (GO:0010008)extracellular region (GO:0005576)intracellular iron ion homeostasis (GO:0006879)metal ion transport (GO:0030001)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of protein ubiquitination (GO:0031398)positive regulation of protein ubiquitination (GO:0031398)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)synapse (GO:0045202)ubiquitin-dependent protein catabolic process (GO:0006511)vacuolar transport (GO:0007034)

Expression (TPM)

TFs regulating NDFIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for NDFIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDFIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NDFIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDFIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:141,811,578–141,812,181	296.9 kb	Distal (>10kb) Multiome	243
chr5:141,816,277–141,817,287	292.0 kb	Distal (>10kb) Multiome	210
chr5:141,838,853–141,839,539	269.5 kb	Distal (>10kb) Multiome	185
chr5:141,845,184–141,846,305	263.0 kb	Distal (>10kb) Multiome	188
chr5:141,848,609–141,851,214	259.4 kb	Distal (>10kb) Multiome	892
chr5:141,858,059–141,858,606	250.5 kb	Distal (>10kb) Multiome	80
chr5:141,875,925–141,877,406	232.5 kb	Distal (>10kb) Multiome	506
chr5:141,877,575–141,879,487	230.3 kb	Distal (>10kb) Multiome	693
chr5:141,923,268–141,924,400	184.9 kb	Distal (>10kb) Multiome	922
chr5:141,968,679–141,969,625	139.7 kb	Distal (>10kb) Multiome	966
chr5:142,012,158–142,013,413	95.8 kb	Distal (>10kb) Multiome	665
chr5:142,083,687–142,084,682	24.7 kb	Distal (>10kb) Multiome	113
chr5:142,108,404–142,109,356	16 bp	At TSS Multiome	759
chr5:142,169,261–142,169,978	60.8 kb	Distal (>10kb) Multiome	405
chr5:142,175,265–142,176,514	67.0 kb	Distal (>10kb) Multiome	230
chr5:142,279,944–142,281,216	171.6 kb	Distal (>10kb) Multiome	416
chr5:142,290,346–142,291,338	182.1 kb	Distal (>10kb) Multiome	377
chr5:142,295,103–142,296,598	186.7 kb	Distal (>10kb) Multiome	308
chr5:142,324,006–142,326,913	217.4 kb	Distal (>10kb) Multiome	1042
chr5:142,355,728–142,357,672	248.3 kb	Distal (>10kb) Multiome	894
chr5:142,359,659–142,361,148	251.6 kb	Distal (>10kb) Multiome	721
chr5:142,362,584–142,363,543	254.2 kb	Distal (>10kb) Multiome	653

Genome Browser

Genomic view of the NDFIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.