Predicted to enable lipid binding activity. Predicted to be involved in neuromuscular synaptic transmission and positive regulation of actin filament polymerization. Predicted to act upstream of or within several processes, including import into nucleus; inflammatory response; and response to hydrogen peroxide. Predicted to be located in cuticular plate. Predicted to be part of protein-containing complex. Predicted to be active in cytosol; neuromuscular junction; and recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for FCHSD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCHSD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCHSD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:141,407,865–141,408,477 | 243.3 kb | Distal (>10kb) Multiome | 109 | |
| chr5:141,417,522–141,418,139 | 233.7 kb | Distal (>10kb) Multiome | 106 | |
| chr5:141,475,524–141,476,908 | 175.5 kb | Distal (>10kb) Multiome | 402 | |
| chr5:141,484,493–141,485,507 | 166.5 kb | Distal (>10kb) Multiome | 189 | |
| chr5:141,508,593–141,509,337 | 142.4 kb | Distal (>10kb) Multiome | 242 | |
| chr5:141,512,198–141,512,900 | 138.8 kb | Distal (>10kb) Multiome | 300 | |
| chr5:141,513,616–141,515,069 | 137.1 kb | Distal (>10kb) Multiome | 392 | |
| chr5:141,524,502–141,525,311 | 126.5 kb | Distal (>10kb) Multiome | 605 | |
| chr5:141,557,658–141,558,135 | 93.5 kb | Distal (>10kb) Multiome | 373 | |
| chr5:141,560,663–141,561,120 | 90.4 kb | Distal (>10kb) Multiome | 327 | |
| chr5:141,617,831–141,619,550 | 32.3 kb | Distal (>10kb) Multiome | 1037 | |
| chr5:141,636,256–141,638,491 | 14.5 kb | Distal (>10kb) Multiome | 852 | |
| chr5:141,650,837–141,651,870 | 33 bp | At TSS Multiome | 438 | |
| chr5:141,680,751–141,681,516 | 29.6 kb | Distal (>10kb) Multiome | 257 | |
| chr5:141,681,692–141,682,621 | 30.9 kb | Distal (>10kb) Multiome | 554 | |
| chr5:141,692,108–141,692,560 | 40.9 kb | Distal (>10kb) Multiome | 498 | |
| chr5:141,702,181–141,702,796 | 51.1 kb | Distal (>10kb) Multiome | 351 | |
| chr5:141,811,578–141,812,181 | 160.5 kb | Distal (>10kb) Multiome | 243 | |
| chr5:141,816,277–141,817,287 | 165.4 kb | Distal (>10kb) Multiome | 210 | |
| chr5:141,838,853–141,839,539 | 187.9 kb | Distal (>10kb) Multiome | 185 | |
| chr5:141,845,184–141,846,305 | 194.3 kb | Distal (>10kb) Multiome | 188 | |
| chr5:141,848,609–141,851,214 | 198.2 kb | Distal (>10kb) Multiome | 892 | |
| chr5:141,858,059–141,858,606 | 206.9 kb | Distal (>10kb) Multiome | 80 | |
| chr5:141,875,925–141,877,406 | 224.8 kb | Distal (>10kb) Multiome | 506 | |
| chr5:141,877,575–141,879,487 | 227.3 kb | Distal (>10kb) Multiome | 693 | |
| chr5:141,923,268–141,924,400 | 272.5 kb | Distal (>10kb) Multiome HiCAR | 922 | |
| chr5:141,968,679–141,969,625 | 317.7 kb | Distal (>10kb) Multiome HiCAR | 966 |
Genomic view of the FCHSD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.