The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for RNF14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:141,650,837–141,651,870 | 317.7 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr5:141,680,751–141,681,516 | 288.1 kb | Distal (>10kb) Multiome HiCAR | 257 | |
| chr5:141,681,692–141,682,621 | 286.8 kb | Distal (>10kb) Multiome HiCAR | 554 | |
| chr5:141,692,108–141,692,560 | 276.8 kb | Distal (>10kb) Multiome HiCAR | 498 | |
| chr5:141,702,181–141,702,796 | 266.7 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr5:141,795,082–141,795,688 | 173.8 kb | Distal (>10kb) Multiome | 25 | |
| chr5:141,811,578–141,812,181 | 157.2 kb | Distal (>10kb) Multiome | 243 | |
| chr5:141,816,277–141,817,287 | 152.3 kb | Distal (>10kb) Multiome | 210 | |
| chr5:141,838,853–141,839,539 | 129.8 kb | Distal (>10kb) Multiome | 185 | |
| chr5:141,845,184–141,846,305 | 123.4 kb | Distal (>10kb) Multiome | 188 | |
| chr5:141,848,609–141,851,214 | 119.7 kb | Distal (>10kb) Multiome | 892 | |
| chr5:141,858,059–141,858,606 | 110.8 kb | Distal (>10kb) Multiome | 80 | |
| chr5:141,875,925–141,877,406 | 92.8 kb | Distal (>10kb) Multiome | 506 | |
| chr5:141,877,575–141,879,487 | 90.6 kb | Distal (>10kb) Multiome | 693 | |
| chr5:141,923,268–141,924,400 | 45.2 kb | Distal (>10kb) Multiome | 922 | |
| chr5:141,960,608–141,961,018 | 8.1 kb | Proximal (<10kb) | 418 | |
| chr5:141,968,679–141,969,625 | 5 bp | At TSS Multiome | 966 | |
| chr5:142,012,158–142,013,413 | 43.9 kb | Distal (>10kb) Multiome | 665 | |
| chr5:142,083,687–142,084,682 | 115.0 kb | Distal (>10kb) Multiome | 113 | |
| chr5:142,108,404–142,109,356 | 139.7 kb | Distal (>10kb) Multiome | 759 | |
| chr5:142,169,261–142,169,978 | 200.5 kb | Distal (>10kb) Multiome | 405 | |
| chr5:142,175,265–142,176,514 | 206.7 kb | Distal (>10kb) Multiome | 230 |
Genomic view of the RNF14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.