chr4:945,351–946,054

chr4 : 945,351 – 946,054

703 bp 73 TFs 13 linked genes

This 703 bp open chromatin element is linked to 13 target genes and is bound by 73 transcription factors.

Linked Genes

13 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TMEM175		13.1 kb	Distal	Multiome
GAK		13.2 kb	Distal	Multiome
DGKQ		28.0 kb	Distal	Multiome
IDUA		41.4 kb	Distal	Multiome
FGFRL1		66.0 kb	Distal	Multiome
PCGF3-AS1		163.7 kb	Distal	Multiome
RNF212		168.0 kb	Distal	Multiome
ENSG00000251652		168.0 kb	Distal	Multiome
SPON2		227.2 kb	Distal	Multiome
PCGF3		239.8 kb	Distal	Multiome
ATP5ME		271.3 kb	Distal	Multiome
MYL5		272.0 kb	Distal	Multiome
PDE6B		320.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

73 transcription factors

ChIP HCT-116 GSE103894.APC.HCT-116 291 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 143 bp overlap

ARID1B 1 dataset

ChIP Hep-G2 GSE69566.ARID1B.Hep-G2 273 bp overlap

ARID4A 1 dataset

ChIP Hep-G2 ENCSR386UBO.ARID4A.Hep-G2 210 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 501 bp overlap

ChIP Hep-G2 ENCSR402ZCY.ATF3.Hep-G2 145 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 548 bp overlap

BMPR1A 1 dataset

ChIP HUVEC-C GSE60156.BMPR1A.HUVEC-C 316 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 393 bp overlap

BRD4 2 datasets

ChIP COLO-741 GSE73319.BRD4.COLO-741 209 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 473 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 132 bp overlap

CTCF 2 datasets

ChIP IMR-90 GSE43070.CTCF.IMR-90 119 bp overlap

ChIP choroid-plexus_epithelial ENCSR000DTL.CTCF.choroid-plexus_epithelial 257 bp overlap

DNMT3B 2 datasets

ChIP HUES-8 GSE99346.DNMT3B.HUES-8 117 bp overlap

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 131 bp overlap

EGR1 3 datasets

ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 344 bp overlap

ChIP K-562 ENCSR000BNE.EGR1.K-562 141 bp overlap

ChIP K562 ENCFF006PJY 245 bp overlap

ChIP GM12878 ENCSR000BMB.ELF1.GM12878 300 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 178 bp overlap

ESR1 2 datasets

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 109 bp overlap

ChIP breast_tumor_Male_21 GSE104399.ESR1.breast_tumor_Male_21 64 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 255 bp overlap

FOXA1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 232 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 481 bp overlap

ChIP DE DE-FOXA2-2 488 bp overlap

ChIP HepG2 ENCFF533COJ 297 bp overlap

GABPA 2 datasets

ChIP WA01 ENCSR000BIW.GABPA.WA01 236 bp overlap

ChIP WA01 ENCSR000BIW.GABPA.WA01 54 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 327 bp overlap

ChIP DE DE-GATA6-2 283 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 263 bp overlap

HDAC2 1 dataset

ChIP Hep-G2 ENCSR000BMC.HDAC2.Hep-G2 262 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 222 bp overlap

HIVEP1 1 dataset

ChIP Hep-G2 ENCSR697WMX.HIVEP1.Hep-G2 181 bp overlap

HMGXB4 1 dataset

ChIP Hep-G2 ENCSR174GOO.HMGXB4.Hep-G2 187 bp overlap

ChIP HEK293_E419Q GSE88976.KLF5.HEK293_E419Q 202 bp overlap

ChIP Hep-G2 ENCSR757EKM.KLF6.Hep-G2 127 bp overlap

KMT2A 1 dataset

ChIP Hep-G2 ENCSR692GFR.KMT2A.Hep-G2 202 bp overlap

LIN54 3 datasets

ChIP Hep-G2 ENCSR597MCV.LIN54.Hep-G2 372 bp overlap

ChIP HepG2 ENCFF662XDE 616 bp overlap

ChIP HepG2 ENCFF662XDE 623 bp overlap

ChIP Hep-G2 ENCSR168DYA.MAX.Hep-G2 379 bp overlap

ChIP HepG2 ENCFF507HCX 391 bp overlap

MTA1 2 datasets

ChIP Hep-G2 ENCSR983KRB.MTA1.Hep-G2 174 bp overlap

ChIP Hep-G2 ENCSR983KRB.MTA1.Hep-G2 349 bp overlap

ChIP Hep-G2 ENCSR441KFW.MXD4.Hep-G2 348 bp overlap

POU2F1 1 dataset

ChIP HepG2 ENCFF422JZU 467 bp overlap

POU5F1 1 dataset

ChIP hiPSC GSE56567.POU5F1.hiPSC 107 bp overlap

PRDM10 2 datasets

ChIP Hep-G2 ENCSR289PSX.PRDM10.Hep-G2 462 bp overlap

ChIP HepG2 ENCFF324FNA 521 bp overlap

RAD21 3 datasets

ChIP Hep-G2 ENCSR000EEG.RAD21.Hep-G2 122 bp overlap

ChIP K-562 ENCSR000BKV.RAD21.K-562 101 bp overlap

ChIP hiPSC_parental-line GSE106870.RAD21.hiPSC_parental-line 156 bp overlap

REST 2 datasets

ChIP Hep-G2 ENCSR000BOT.REST.Hep-G2 197 bp overlap

ChIP WA01 ENCSR000BHM.REST.WA01 171 bp overlap

SAP130 1 dataset

ChIP HepG2 ENCFF892EHZ 482 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 247 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 262 bp overlap

SMAD3 1 dataset

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 136 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 302 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 225 bp overlap

SMARCC1 1 dataset

ChIP hiPSC GSE124903.SMARCC1.hiPSC 236 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 295 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 583 bp overlap

ChIP Hep-G2 ENCSR019NPF.SP5.Hep-G2 149 bp overlap

SUZ12 1 dataset

ChIP hiPSC GSE124903.SUZ12.hiPSC 244 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 221 bp overlap

TARDBP 1 dataset

ChIP K-562 GSE120104.TARDBP.K-562 181 bp overlap

TBX2 2 datasets

ChIP HepG2 ENCFF811TLA 380 bp overlap

ChIP HepG2 ENCFF811TLA 579 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 270 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 124 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 141 bp overlap

UBTF 2 datasets

ChIP HepG2 ENCFF424RNN 342 bp overlap

ChIP HepG2 ENCFF424RNN 541 bp overlap

ChIP K-562 GSE111469.USF2.K-562 67 bp overlap

XRCC5 1 dataset

ChIP HepG2 ENCFF680LVJ 481 bp overlap

ZBTB7A 1 dataset

ChIP Hep-G2 ENCSR000BQA.ZBTB7A.Hep-G2 161 bp overlap

ZBTB7B 1 dataset

ChIP Hep-G2 ENCSR322ULL.ZBTB7B.Hep-G2 251 bp overlap

ChIP HEK293T GSE78099.ZIM3.HEK293T 108 bp overlap

ZNF217 1 dataset

ChIP Hep-G2 ENCSR055FQB.ZNF217.Hep-G2 142 bp overlap

ZNF274 1 dataset

ChIP Hep-G2 ENCSR871VNN.ZNF274.Hep-G2 194 bp overlap

ZNF276 2 datasets

ChIP Hep-G2 ENCSR076KLJ.ZNF276.Hep-G2 176 bp overlap

ChIP Hep-G2 ENCSR076KLJ.ZNF276.Hep-G2 235 bp overlap

ZNF341 1 dataset

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 209 bp overlap

ZNF407 1 dataset

ChIP Hep-G2 ENCSR005WGY.ZNF407.Hep-G2 329 bp overlap

ZNF501 1 dataset

ChIP Hep-G2 ENCSR227PHM.ZNF501.Hep-G2 368 bp overlap

ZNF550 1 dataset

ChIP Hep-G2 ENCSR198BHH.ZNF550.Hep-G2 280 bp overlap

ZNF572 1 dataset

ChIP Hep-G2 ENCSR663CTC.ZNF572.Hep-G2 440 bp overlap

ZNF598 1 dataset

ChIP Hep-G2 ENCSR173NAL.ZNF598.Hep-G2 257 bp overlap

ZNF691 1 dataset

ChIP HepG2 ENCFF427OHT 400 bp overlap

ZNF777 1 dataset

ChIP Hep-G2 ENCSR068ZQR.ZNF777.Hep-G2 124 bp overlap

ZNF782 1 dataset

ChIP HepG2 ENCFF449SAF 446 bp overlap

ZNF883 1 dataset

ChIP Hep-G2 ENCSR882YYL.ZNF883.Hep-G2 326 bp overlap

ZNF891 3 datasets

ChIP Hep-G2 ENCSR020CLV.ZNF891.Hep-G2 276 bp overlap

ChIP HepG2 ENCFF491CCY 258 bp overlap

ChIP HepG2 ENCFF491CCY 531 bp overlap