The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DGKQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGKQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGKQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:673,501–675,336 | 299.2 kb | Distal (>10kb) Multiome | 920 | |
| chr4:680,919–681,550 | 292.2 kb | Distal (>10kb) Multiome | 275 | |
| chr4:688,280–689,636 | 284.3 kb | Distal (>10kb) Multiome | 218 | |
| chr4:705,313–706,398 | 267.9 kb | Distal (>10kb) Multiome | 613 | |
| chr4:781,187–782,732 | 191.6 kb | Distal (>10kb) Multiome | 893 | |
| chr4:825,232–826,278 | 147.8 kb | Distal (>10kb) Multiome | 317 | |
| chr4:826,462–827,691 | 146.6 kb | Distal (>10kb) Multiome | 180 | |
| chr4:931,599–932,710 | 41.2 kb | Distal (>10kb) Multiome | 818 | |
| chr4:945,351–946,054 | 28.0 kb | Distal (>10kb) Multiome | 73 | |
| chr4:970,148–971,077 | 2.5 kb | Proximal (<10kb) | 117 | |
| chr4:972,792–974,408 | 29 bp | At TSS Multiome | 437 | |
| chr4:985,192–985,448 | 1.4 kb | Proximal (<10kb) | 378 | |
| chr4:986,645–987,589 | 13.6 kb | Distal (>10kb) Multiome | 723 | |
| chr4:1,002,360–1,003,561 | 29.6 kb | Distal (>10kb) Multiome | 176 | |
| chr4:1,008,768–1,012,870 | 37.9 kb | Distal (>10kb) Multiome | 793 | |
| chr4:1,113,486–1,113,937 | 140.1 kb | Distal (>10kb) Multiome | 183 | |
| chr4:1,167,206–1,167,987 | 194.0 kb | Distal (>10kb) Multiome | 553 | |
| chr4:1,247,634–1,250,121 | 275.4 kb | Distal (>10kb) Multiome | 835 |
Genomic view of the DGKQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.