This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for RNF212. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF212 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF212, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:825,232–826,278 | 287.8 kb | Distal (>10kb) Multiome | 317 | |
| chr4:931,599–932,710 | 181.2 kb | Distal (>10kb) Multiome | 818 | |
| chr4:945,351–946,054 | 168.0 kb | Distal (>10kb) Multiome | 73 | |
| chr4:972,792–974,408 | 140.0 kb | Distal (>10kb) Multiome | 437 | |
| chr4:986,645–987,589 | 126.4 kb | Distal (>10kb) Multiome | 723 | |
| chr4:1,002,360–1,003,561 | 110.4 kb | Distal (>10kb) Multiome | 176 | |
| chr4:1,008,768–1,012,870 | 102.1 kb | Distal (>10kb) Multiome | 793 | |
| chr4:1,113,486–1,113,937 | 145 bp | At TSS Multiome | 183 | |
| chr4:1,167,206–1,167,987 | 54.0 kb | Distal (>10kb) Multiome | 553 | |
| chr4:1,247,634–1,250,121 | 135.4 kb | Distal (>10kb) Multiome | 835 | |
| chr4:1,289,220–1,290,349 | 176.2 kb | Distal (>10kb) Multiome | 769 | |
| chr4:1,309,299–1,309,921 | 196.0 kb | Distal (>10kb) Multiome | 461 | |
| chr4:1,345,929–1,347,890 | 233.5 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the RNF212 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.