The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PCGF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCGF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCGF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:473,613–474,432 | 231.6 kb | Distal (>10kb) Multiome | 745 | |
| chr4:498,731–499,543 | 206.6 kb | Distal (>10kb) Multiome | 869 | |
| chr4:575,294–576,132 | 130.4 kb | Distal (>10kb) Multiome | 154 | |
| chr4:663,207–664,324 | 42.1 kb | Distal (>10kb) Multiome | 298 | |
| chr4:673,501–675,336 | 31.4 kb | Distal (>10kb) Multiome | 920 | |
| chr4:680,919–681,550 | 24.4 kb | Distal (>10kb) Multiome | 275 | |
| chr4:688,280–689,636 | 16.5 kb | Distal (>10kb) Multiome | 218 | |
| chr4:705,313–706,398 | 133 bp | At TSS Multiome | 613 | |
| chr4:781,187–782,732 | 76.2 kb | Distal (>10kb) Multiome | 893 | |
| chr4:825,232–826,278 | 120.0 kb | Distal (>10kb) Multiome | 317 | |
| chr4:826,462–827,691 | 121.2 kb | Distal (>10kb) Multiome | 180 | |
| chr4:931,599–932,710 | 226.5 kb | Distal (>10kb) Multiome | 818 | |
| chr4:945,351–946,054 | 239.8 kb | Distal (>10kb) Multiome | 73 | |
| chr4:972,792–974,408 | 267.8 kb | Distal (>10kb) Multiome | 437 | |
| chr4:986,645–987,589 | 281.3 kb | Distal (>10kb) Multiome | 723 | |
| chr4:1,002,360–1,003,561 | 297.4 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the PCGF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.