The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FGFRL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGFRL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGFRL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:781,187–782,732 | 229.6 kb | Distal (>10kb) Multiome | 893 | |
| chr4:825,232–826,278 | 185.8 kb | Distal (>10kb) Multiome | 317 | |
| chr4:931,599–932,710 | 79.3 kb | Distal (>10kb) Multiome | 818 | |
| chr4:945,351–946,054 | 66.0 kb | Distal (>10kb) Multiome | 73 | |
| chr4:972,792–974,408 | 38.0 kb | Distal (>10kb) Multiome | 437 | |
| chr4:986,645–987,589 | 24.5 kb | Distal (>10kb) Multiome | 723 | |
| chr4:1,002,360–1,003,561 | 8.4 kb | Proximal (<10kb) Multiome | 176 | |
| chr4:1,008,768–1,012,870 | 138 bp | At TSS Multiome | 793 | |
| chr4:1,113,486–1,113,937 | 102.1 kb | Distal (>10kb) Multiome | 183 | |
| chr4:1,167,206–1,167,987 | 156.0 kb | Distal (>10kb) Multiome | 553 | |
| chr4:1,247,634–1,250,121 | 237.4 kb | Distal (>10kb) Multiome | 835 | |
| chr4:1,289,220–1,290,349 | 278.2 kb | Distal (>10kb) Multiome | 769 | |
| chr4:1,309,299–1,309,921 | 297.9 kb | Distal (>10kb) Multiome | 461 |
Genomic view of the FGFRL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.