The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARID4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:58,151,365–58,152,866 | 146.4 kb | Distal (>10kb) Multiome | 506 | |
| chr14:58,199,683–58,200,642 | 98.5 kb | Distal (>10kb) Multiome | 673 | |
| chr14:58,244,179–58,245,432 | 53.7 kb | Distal (>10kb) Multiome | 789 | |
| chr14:58,297,373–58,299,879 | 328 bp | At TSS Multiome | 1029 | |
| chr14:58,395,454–58,396,694 | 97.5 kb | Distal (>10kb) Multiome | 791 | |
| chr14:58,426,724–58,428,061 | 129.1 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the ARID4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.