This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Cluster | Dir | NES | padj | Bind | OR | padj (bind) |
|---|
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by MTA1 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to MTA1 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where MTA1 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for MTA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:105,167,331–105,169,463 | 251.0 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 238.8 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 171.5 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 118.7 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 105.4 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 67.7 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 21.5 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 8.6 kb | Proximal (<10kb) Multiome | 384 | |
| chr14:105,414,595–105,414,761 | 5.3 kb | Proximal (<10kb) | 161 | |
| chr14:105,414,940–105,415,397 | 4.9 kb | Proximal (<10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 163 bp | At TSS Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 28.8 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 54.3 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 61.0 kb | Distal (>10kb) Multiome | 784 | |
| chr14:105,485,648–105,486,379 | 65.9 kb | Distal (>10kb) Multiome | 424 | |
| chr14:105,486,576–105,487,923 | 67.2 kb | Distal (>10kb) Multiome | 369 | |
| chr14:105,489,310–105,492,133 | 71.0 kb | Distal (>10kb) Multiome | 1014 | |
| chr14:105,526,110–105,527,233 | 106.5 kb | Distal (>10kb) Multiome | 270 | |
| chr14:105,528,085–105,528,965 | 108.5 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the MTA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.