TFs regulating ENSG00000251652 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000251652. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000251652 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000251652

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000251652, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:825,232–826,278	287.8 kb	Distal (>10kb) Multiome	317
chr4:826,462–827,691	286.6 kb	Distal (>10kb) Multiome	180
chr4:931,599–932,710	181.3 kb	Distal (>10kb) Multiome	818
chr4:945,351–946,054	168.0 kb	Distal (>10kb) Multiome	73
chr4:972,792–974,408	140.0 kb	Distal (>10kb) Multiome	437
chr4:986,645–987,589	126.5 kb	Distal (>10kb) Multiome	723
chr4:1,002,360–1,003,561	110.4 kb	Distal (>10kb) Multiome	176
chr4:1,008,768–1,012,870	102.2 kb	Distal (>10kb) Multiome	793
chr4:1,113,486–1,113,937	71 bp	At TSS Multiome	183
chr4:1,167,206–1,167,987	53.9 kb	Distal (>10kb) Multiome	553
chr4:1,247,634–1,250,121	135.3 kb	Distal (>10kb) Multiome	835
chr4:1,289,220–1,290,349	176.2 kb	Distal (>10kb) Multiome	769
chr4:1,309,299–1,309,921	195.9 kb	Distal (>10kb) Multiome	461
chr4:1,345,929–1,347,890	233.4 kb	Distal (>10kb) Multiome	864

Genome Browser

Genomic view of the ENSG00000251652 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.