chr2:10,873,608–10,874,413

chr2 : 10,873,608 – 10,874,413

805 bp 91 TFs 6 linked genes

This 805 bp open chromatin element is linked to 6 target genes and is bound by 91 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
KCNF1		37.9 kb	Distal	Multiome
PDIA6		61.3 kb	Distal	Multiome
ATP6V1C2		152.4 kb	Distal	Multiome
NOL10		184.1 kb	Distal	Multiome
C2orf50		259.1 kb	Distal	Multiome
SLC66A3		281.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

91 transcription factors

ChIP prostate-cancer_PDX_35 GSE130408.AR.prostate-cancer_PDX_35 159 bp overlap

ARID1A 1 dataset

ChIP 12Z GSE129781.ARID1A.12Z 384 bp overlap

ASH2L 1 dataset

ChIP GM12878 ENCSR849WCQ.ASH2L.GM12878 285 bp overlap

ChIP GM12878 ENCSR000BQK.ATF2.GM12878 166 bp overlap

BAF155 1 dataset

ChIP VCaP_shERG GSE110655.BAF155.VCaP_shERG 171 bp overlap

ChIP GM12878 ENCFF954REE 231 bp overlap

ChIP GM12878 ENCSR000BNQ.BCL3.GM12878 165 bp overlap

BHLHE22 3 datasets

Motif DE_36h DE_36h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

BRD2 3 datasets

ChIP HCC1806_BAZ2BsiRNA GSE116879.BRD2.HCC1806_BAZ2BsiRNA 270 bp overlap

ChIP HCC1806_NTsiRNA GSE116879.BRD2.HCC1806_NTsiRNA 209 bp overlap

ChIP SK-MEL-147 GSE94488.BRD2.SK-MEL-147 232 bp overlap

BRD4 3 datasets

ChIP GM15850_Syn-TEF1 GSE99402.BRD4.GM15850_Syn-TEF1 173 bp overlap

ChIP HCC1395 GSE63581.BRD4.HCC1395 286 bp overlap

ChIP IMR-90_SENES GSE74238.BRD4.IMR-90_SENES 124 bp overlap

ChIP GM12878 ENCSR372GIN.CBX5.GM12878 104 bp overlap

CDX2 2 datasets

ChIP LS180 GSE31939.CDX2.LS180 224 bp overlap

ChIP adult-duodenal-cell GSE115314.CDX2.adult-duodenal-cell 234 bp overlap

ChIP gastrocnemius-medialis ENCSR428BKN.CTCF.gastrocnemius-medialis 254 bp overlap

Motif DE_36h DE_36h-DUXA_MA0884.2 13 bp overlap

EBF1 4 datasets

ChIP GM12878 ENCFF167CZS 321 bp overlap

ChIP GM12878 ENCFF813OXE 119 bp overlap

ChIP GM12878 ENCSR000DZQ.EBF1.GM12878 147 bp overlap

ChIP LCL GSE75503.EBF1.LCL 251 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 280 bp overlap

ERF::FIGLA 1 dataset

Motif DE_36h DE_36h-ERFFIGLA_MA1934.2 13 bp overlap

ChIP VCaP_ETOH GSE49091.ERG.VCaP_ETOH 201 bp overlap

ChIP VCaP_R1881 GSE49091.ERG.VCaP_R1881 189 bp overlap

ChIP VCaP_shARID1A GSE110655.ERG.VCaP_shARID1A 198 bp overlap

ChIP VCaP_shERG GSE110655.ERG.VCaP_shERG 240 bp overlap

ChIP aortic-endothelial-cell_D24 GSE139377.ERG.aortic-endothelial-cell_D24 203 bp overlap

ChIP aortic-endothelial-cell_D28 GSE139377.ERG.aortic-endothelial-cell_D28 188 bp overlap

ChIP aortic-endothelial-cell_D33 GSE139377.ERG.aortic-endothelial-cell_D33 199 bp overlap

ChIP aortic-endothelial-cell_D5 GSE139377.ERG.aortic-endothelial-cell_D5 169 bp overlap

ChIP MCF-7_Veh GSE93510.ESR1.MCF-7_Veh 309 bp overlap

ChIP 786-O GSE86092.ETS1.786-O 209 bp overlap

FLI1 4 datasets

ChIP A-673 GSE99959.FLI1.A-673 325 bp overlap

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 341 bp overlap

ChIP A-673_2_KRAB_eSOX2_1 GSE106914.FLI1.A-673_2_KRAB_eSOX2_1 246 bp overlap

ChIP CTV-1_DSG_SPI1-mut GSE128835.FLI1.CTV-1_DSG_SPI1-mut 292 bp overlap

FOXA1 1 dataset

ChIP LS180 GSE140533.FOXA1.LS180 73 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 586 bp overlap

ChIP DE DE-FOXA2-2 520 bp overlap

GABPA 7 datasets

ChIP GM12878 ENCFF872TWR 101 bp overlap

ChIP GM12878 ENCSR331HPA.GABPA.GM12878 209 bp overlap

ChIP GM12878 ENCSR000BGC.GABPA.GM12878 90 bp overlap

ChIP SK-N-SH ENCSR000BTG.GABPA.SK-N-SH 149 bp overlap

ChIP VCaP GSE49091.GABPA.VCaP 172 bp overlap

ChIP VCaP_ETOH GSE49091.GABPA.VCaP_ETOH 258 bp overlap

ChIP VCaP_R1881 GSE49091.GABPA.VCaP_R1881 180 bp overlap

GATA4 8 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 234 bp overlap

ChIP DE DE-GATA4-1 603 bp overlap

ChIP DE DE-GATA4-2 572 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 369 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 330 bp overlap

GATA5 3 datasets

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

GATA6 17 datasets

ChIP AGS GSE51936.GATA6.AGS 88 bp overlap

ChIP DE DE-GATA6-1 616 bp overlap

ChIP DE DE-GATA6-2 581 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 478 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 496 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 445 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 575 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 518 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 503 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 231 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 504 bp overlap

ChIP foregut GSE117136.GATA6.foregut 411 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 327 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 234 bp overlap

GRHL2 3 datasets

ChIP HBE GSE46194.GRHL2.HBE 189 bp overlap

ChIP MCF-7-WS8_VEH GSE113092.GRHL2.MCF-7-WS8_VEH 229 bp overlap

ChIP MCF-7_E2_45min GSE109820.GRHL2.MCF-7_E2_45min 207 bp overlap

Gata3 3 datasets

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

HIF1A 1 dataset

ChIP PC-3_hypoxia_siCtrl GSE106305.HIF1A.PC-3_hypoxia_siCtrl 241 bp overlap

HNF4A 1 dataset

ChIP KATO-III GSE114018.HNF4A.KATO-III 333 bp overlap

HOXB13 1 dataset

ChIP prostate-cancer_PDX_170-2 GSE130408.HOXB13.prostate-cancer_PDX_170-2 64 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_36h DE_36h-Hand1Tcf3_MA0092.2 9 bp overlap

IKZF1 1 dataset

ChIP GM12878 ENCFF753XDO 591 bp overlap

ChIP GM12878 ENCSR000BGY.IRF4.GM12878 154 bp overlap

ChIP 786-O GSE86092.JUN.786-O 208 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 404 bp overlap

ChIP HAEC_IL1b_4h GSE89970.JUN.HAEC_IL1b_4h 312 bp overlap

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 287 bp overlap

ChIP U-87MG GSE36354.MED1.U-87MG 173 bp overlap

MEF2B 1 dataset

ChIP GM12878 ENCSR177VFS.MEF2B.GM12878 240 bp overlap

MEIS1 3 datasets

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

MEIS2 3 datasets

Motif DE_36h DE_36h-MEIS2_MA0774.1 8 bp overlap

Motif DE_48h DE_48h-MEIS2_MA0774.1 8 bp overlap

Motif DE_60h DE_60h-MEIS2_MA0774.1 8 bp overlap

MEIS3 3 datasets

Motif DE_36h DE_36h-MEIS3_MA0775.2 7 bp overlap

Motif DE_48h DE_48h-MEIS3_MA0775.2 7 bp overlap

Motif DE_60h DE_60h-MEIS3_MA0775.2 7 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 262 bp overlap

Motif DE_36h DE_36h-MSC_MA0665.1 10 bp overlap

Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap

Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap

ChIP PF-382 GSE94000.MYB.PF-382 372 bp overlap

NFATC3 1 dataset

Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap

NFKB1 1 dataset

ChIP L1236 GSE63736.NFKB1.L1236 242 bp overlap

NFKB2 1 dataset

ChIP L1236 GSE63736.NFKB2.L1236 152 bp overlap

NR2F1 1 dataset

Motif DE_36h DE_36h-NR2F1_MA1537.2 13 bp overlap

Neurod2 3 datasets

Motif DE_36h DE_36h-Neurod2_MA1993.2 6 bp overlap

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Nfatc1 1 dataset

Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap

Nr2e1 1 dataset

Motif DE_36h DE_36h-Nr2e1_MA0676.1 9 bp overlap

Olig2 3 datasets

Motif DE_36h DE_36h-Olig2_MA1997.2 6 bp overlap

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

ChIP T-47D_R5020-A1 GSE126859.PGR.T-47D_R5020-A1 156 bp overlap

PKNOX1 1 dataset

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 356 bp overlap

PKNOX2 3 datasets

Motif DE_36h DE_36h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_48h DE_48h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_60h DE_60h-PKNOX2_MA0783.1 12 bp overlap

POLR2A 2 datasets

ChIP GM19099 ENCFF726IBN 324 bp overlap

ChIP spleen ENCFF044PYR 110 bp overlap

Prdm4 1 dataset

Motif DE_36h DE_36h-Prdm4_MA1647.3 11 bp overlap

Ptf1A 3 datasets

Motif DE_36h DE_36h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_48h DE_48h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_36h DE_36h-RARA_MA0729.1 18 bp overlap

ChIP GM12878 ENCSR785OKZ.RB1.GM12878 237 bp overlap

ChIP LCL GSE75503.RBPJ.LCL 273 bp overlap

RCOR1 1 dataset

ChIP keratinocyte_diff GSE57702.RCOR1.keratinocyte_diff 229 bp overlap

Motif DE_36h DE_36h-REL_MA0101.1 10 bp overlap

RELA 15 datasets

ChIP GM12878 ENCSR000EAG.RELA.GM12878 314 bp overlap

ChIP GM19099 ENCSR000EBI.RELA.GM19099 261 bp overlap

ChIP HAEC_IL1b_4h GSE89970.RELA.HAEC_IL1b_4h 276 bp overlap

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 378 bp overlap

ChIP HUVEC-C_TNF GSE53998.RELA.HUVEC-C_TNF 215 bp overlap

ChIP HUVEC-C_TNF_JQ1 GSE53998.RELA.HUVEC-C_TNF_JQ1 308 bp overlap

ChIP aortic-endothelial-cell_IL1B_D11 GSE139377.RELA.aortic-endothelial-cell_IL1B_D11 206 bp overlap

ChIP aortic-endothelial-cell_IL1B_D14 GSE139377.RELA.aortic-endothelial-cell_IL1B_D14 377 bp overlap

ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 264 bp overlap

ChIP aortic-endothelial-cell_IL1B_D27 GSE139377.RELA.aortic-endothelial-cell_IL1B_D27 207 bp overlap

ChIP aortic-endothelial-cell_IL1B_D28 GSE139377.RELA.aortic-endothelial-cell_IL1B_D28 198 bp overlap

ChIP aortic-endothelial-cell_IL1B_D39 GSE139377.RELA.aortic-endothelial-cell_IL1B_D39 215 bp overlap

ChIP aortic-endothelial-cell_IL1B_D4 GSE139377.RELA.aortic-endothelial-cell_IL1B_D4 332 bp overlap

ChIP aortic-endothelial-cell_IL1B_D47 GSE139377.RELA.aortic-endothelial-cell_IL1B_D47 196 bp overlap

ChIP aortic-endothelial-cell_IL1B_D9 GSE139377.RELA.aortic-endothelial-cell_IL1B_D9 253 bp overlap

RELB 2 datasets

ChIP GM12878 ENCSR387QUV.RELB.GM12878 279 bp overlap

ChIP L1236 GSE63736.RELB.L1236 157 bp overlap

ChIP colorectal-cancer_shCDH1 GSE112555.REST.colorectal-cancer_shCDH1 309 bp overlap

RUNX3 1 dataset

ChIP GM12878 ENCFF395WHA 371 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 486 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 305 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 278 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 400 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 286 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 262 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 648 bp overlap

ChIP GM12878 ENCFF878IIX 397 bp overlap

ChIP GM12878 ENCSR000BMI.SRF.GM12878 105 bp overlap

Stat2 1 dataset

Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap

TCF12 1 dataset

ChIP GM12878 ENCSR000BGZ.TCF12.GM12878 189 bp overlap

TCF3 2 datasets

ChIP GM12878 ENCFF658WIO 297 bp overlap

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 211 bp overlap

TFAP4 3 datasets

Motif DE_36h DE_36h-TFAP4_MA0691.1 10 bp overlap

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

TGIF1 3 datasets

Motif DE_36h DE_36h-TGIF1_MA0796.1 12 bp overlap

Motif DE_48h DE_48h-TGIF1_MA0796.1 12 bp overlap

Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap

TGIF2 3 datasets

Motif DE_36h DE_36h-TGIF2_MA0797.1 12 bp overlap

Motif DE_48h DE_48h-TGIF2_MA0797.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2_MA0797.1 12 bp overlap

TGIF2LX 3 datasets

Motif DE_36h DE_36h-TGIF2LX_MA1571.1 12 bp overlap

Motif DE_48h DE_48h-TGIF2LX_MA1571.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2LX_MA1571.1 12 bp overlap

TGIF2LY 3 datasets

Motif DE_36h DE_36h-TGIF2LY_MA1572.1 12 bp overlap

Motif DE_48h DE_48h-TGIF2LY_MA1572.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2LY_MA1572.1 12 bp overlap

TRPS1 3 datasets

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Tcf12 3 datasets

Motif DE_36h DE_36h-Tcf12_MA0521.3 6 bp overlap

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Tcf21 3 datasets

Motif DE_36h DE_36h-Tcf21_MA0832.2 10 bp overlap

Motif DE_48h DE_48h-Tcf21_MA0832.2 10 bp overlap

Motif DE_60h DE_60h-Tcf21_MA0832.2 10 bp overlap

Twist2 3 datasets

Motif DE_36h DE_36h-Twist2_MA0633.3 6 bp overlap

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ChIP GM12878 ENCFF908JTL 345 bp overlap

ChIP GM12878 ENCFF908JTL 345 bp overlap

ZFP69B 1 dataset

ChIP HEK293T GSE78099.ZFP69B.HEK293T 121 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 231 bp overlap

ZNF317 3 datasets

Motif DE_36h DE_36h-ZNF317_MA1593.2 8 bp overlap

Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap

Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap

ZNF519 1 dataset

ChIP HEK293T GSE78099.ZNF519.HEK293T 65 bp overlap

ZNF687 2 datasets

ChIP GM12878 ENCFF233SGE 457 bp overlap

ChIP GM12878 ENCSR859FDL.ZNF687.GM12878 424 bp overlap

ZNF692 3 datasets

Motif DE_36h DE_36h-ZNF692_MA1986.2 8 bp overlap

Motif DE_48h DE_48h-ZNF692_MA1986.2 8 bp overlap

Motif DE_60h DE_60h-ZNF692_MA1986.2 8 bp overlap