This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BCL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,747,085–44,747,789 | at TSS | At TSS | 653 | |
| chr19:44,747,929–44,749,009 | 225 bp | At TSS | 578 | |
| chr19:44,753,339–44,753,660 | 5.6 kb | Proximal (<10kb) | 645 | |
| chr19:44,754,418–44,754,642 | 6.7 kb | Proximal (<10kb) | 381 | |
| chr19:44,757,112–44,758,480 | 9.4 kb | Proximal (<10kb) | 209 | |
| chr19:44,758,633–44,759,104 | 9.9 kb | Proximal (<10kb) | 80 |
Genomic view of the BCL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.