MEIS3

Meis homeobox 3 | DKFZp547H236, MRG2

This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

Member of: DE-4 DE-4.16 Developmental clusters: GC2

Biological processes 19 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)angiogenesis (GO:0001525)animal organ morphogenesis (GO:0009887)brain development (GO:0007420)chromatin (GO:0000785)embryonic pattern specification (GO:0009880)eye development (GO:0001654)hemopoiesis (GO:0030097)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell population proliferation (GO:0008284)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating MEIS3 0 TFs

Transcription factors with Perturb-seq knockdown data for MEIS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEIS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MEIS3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEIS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:47,130,439–47,131,651	288.5 kb	Distal (>10kb) Multiome	908
chr19:47,157,325–47,158,494	261.7 kb	Distal (>10kb) Multiome	271
chr19:47,196,586–47,197,452	222.5 kb	Distal (>10kb) Multiome	94
chr19:47,225,386–47,231,990	191.5 kb	Distal (>10kb) Multiome	1389
chr19:47,240,827–47,241,572	178.1 kb	Distal (>10kb) Multiome	616
chr19:47,242,713–47,243,645	176.2 kb	Distal (>10kb) Multiome	568
chr19:47,243,835–47,244,896	174.9 kb	Distal (>10kb) Multiome	1001
chr19:47,256,041–47,258,057	162.2 kb	Distal (>10kb) Multiome	907
chr19:47,272,778–47,275,890	145.9 kb	Distal (>10kb) Multiome	931
chr19:47,348,695–47,349,758	70.1 kb	Distal (>10kb) Multiome	766
chr19:47,406,825–47,407,408	12.0 kb	Distal (>10kb) Multiome	333
chr19:47,418,863–47,419,563	at TSS	At TSS	189
chr19:47,421,964–47,422,277	2.7 kb	Proximal (<10kb)	142
chr19:47,427,132–47,428,809	8.0 kb	Proximal (<10kb) Multiome	506
chr19:47,429,865–47,430,531	11.0 kb	Distal (>10kb) Multiome	438
chr19:47,447,043–47,448,262	28.4 kb	Distal (>10kb) Multiome	510
chr19:47,471,631–47,472,340	52.7 kb	Distal (>10kb) Multiome	500
chr19:47,479,940–47,480,772	60.9 kb	Distal (>10kb) Multiome	147
chr19:47,483,636–47,484,543	64.9 kb	Distal (>10kb) Multiome	841
chr19:47,514,152–47,515,901	96.0 kb	Distal (>10kb) Multiome	895
chr19:47,600,223–47,600,983	181.2 kb	Distal (>10kb) Multiome	807
chr19:47,607,980–47,609,479	189.5 kb	Distal (>10kb) Multiome	832
chr19:47,647,803–47,648,987	229.2 kb	Distal (>10kb) Multiome	693
chr19:47,697,956–47,698,391	278.9 kb	Distal (>10kb) Multiome	453

Genome Browser

Genomic view of the MEIS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.